Conclusions
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1.
Sulfaguanidine, while not as readily absorbed from the intestine as other sulfonamides, is, nevertheless, absorbed to some extent. When doses of 10 to 15 grams are given daily, the blood levels may reach 10 mg. %.
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2.
Although reactions may occur during its administration, sulfaguanidine appears to be less toxic than other commonly used sulfonamides.
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3.
Sulfaguanidine, in doses of 10 to 15 grams daily, usually decreases the bacterial count of the feces markedly and transforms the flora from one predominantly coliform in type to one composed almost entirely of gram positive organisms.
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4.
Sulfaguanidine is of no value in the treatment of Paratyphoid B infection. It apparently has no advantage over other sulfonamides in the treatment of lymphogranuloma venereum. The long continued use of sulfaguanidine in chronic, non specific ulcerative colitis has not yielded any striking therapeutic results.
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Marshall, E. K., Jr., Bratton, A. C., White, H. J. and Litchfleld, J. T., Jr.: Sulfanilylguanidine: A Chemotherapeutic Agent for Intestinal Infections.Bull. Johns Hopkins Hospital, 67:163, 1940.
Marshall, E. K., Jr., Bratton, A. C., Edwards, Lydia B. and Walker, Ethel: Sulfanilylguanidine in the Treatment of Acute Bacillary Dysentery in Children.Bull. Johns Hopkins Hospital, 68:94, 1941.
Lyon, G. M.: Chemotherapy in Acute Bacillary Dysentery : II. Clinical Use of Sulfanilylguanidine.West Virginia Med. J., 37:54, 1941. Sulfa.nilylguanidine Treatment of Acute Bacillary Dysentery.U. S. Naval Med. Bull., 39:278, April, 1941.
Firor, W. M. and Jonas, A. F.: The Use of Sulfaguanidine in Surgical Patients.Ann. Surg., 114:19, 1941. Stone, H. B., Shipley, A. M. and Brady, L.: Individual Discussions of Paper by Firor and Jonas.Surgery, 9:317-318, Feb., 1941.
Stone, H. B.: Discussion of paper, Mortality Factors in Surgical Treatment of Ulcerative Colitis. Cave, H. W. and Thompson, J. E. :Ann. Surg., 114:46, 1941.
Dack, G. M., Kirsner, J. B., Dragstedt, L. R. and Johnson, R.: A Study of Bacterium Necrophorum in Chronic Ulcerative Co- litis and of the Effect of Sulfanilamide in Treatment.Am. J Dig. Dis., 6:305, 1939.
Black, S., McKibbin, J. M. and Elrehjem, C. A.: Use of Sulfaguanidine in Nutrition Experiments.Proc. Soc. Exper. Biol and Med., 47:308, 1941.
MacKenzie, J. B., MacKenzie, C. G. and McCoIIum, E. V.: The Effect of Sulfanilylguanidine on the Thyroid of the Rat.Science, 94:618, 1941.
Corwin, W. C., Jr.: Studies on the Chronic Toxicity of Sulfaguanidine.Bull. Johns Hopkins Hosp., 69:39, 1941.
Firor, W. M. and Poth, E. J.: Intestinal Antisepsis with Special Reference to Sulfanilylguanidine.Ann. Surg., 114:663, 1941.
Bornstein, S. and Strauss, L.: Selective Action of Sulfanilylguanidine on Different Salmonella Types and Its Practical Importance.Proc. Soc. Exper. Biol. and Med., 47:112, 1941.
Rodaniche, E. C.: Sulfanilylguanidine and Sulfanilamide in the Treatment of Lymphogranuloma Venereum Infections of Mice.J. Infect. Dis., 69:138, Sept.-Oct., 1941.
Richardson, A. P.: Comparative Effects of Sulfonamide Compounds as to Anemia and Cyanosis.J. Pharm. and Exper. Therap., 72:99, 1941.
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Read before the Central Society for Clinical Rese?rch, November 8, 1941, and the Chicago Society of Internal Medicine, November 24, 1841.
The sulfaguanidine was supplied in generous quantities by Dr. David A. Bryce, of the Lederle Laboratories, Pearl River, N. Y.
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Kirsner, J.B., Rodaniche, E.C. & Lincoln Palmer, W. The use of sulfaguanidine in non-specific ulcerative colitis and other infections of the bowel. Jour. D. D. 9, 229–233 (1942). https://doi.org/10.1007/BF02997417
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DOI: https://doi.org/10.1007/BF02997417