Skip to main content
Log in

Studies on the antitumor activity of polyphase liposome of ricinoleic acid containing selenium

  • Basic Investigation
  • Published:
Chinese Journal of Cancer Research


Emulsion and polyphase liposome (PL) of ricinoleic acid (RA) and RA containing selenium (Se-RA) were prepared by tween- 80 treatment and injection-ultrasonic method. Their antitumor effects were testedin vitro andin vivo. As a result, the emulsion of RA (91) and Sc-RA (92) can completely kill the mouse ascites tumor cells of S180 in vitro (500 µg/ml). While, 97% cells of the control group still survive. When testedin vim, 91 and 92 were injected into mice peritoneally (200 mg/Kg/day) for 7 days, their inhibit rate on S180 are 30. 6% (P<0. 05) and 33. 3% (P<0.05) respectively. For the PL of RA (113) and Se-RA (114), the inhibit rate are 58% (P<0. 001) and 61.4% (P<0. 001) respectively (400 mg/kg/day). The result of3H-TdR incorporation experiment indicates that the possible antitumor mechanism of Se-Ra is that it can inhibit the incorporation of3H- TdR into tumor cells and hense inhibit the DNA synthesis of the tumor cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others


  1. Isreal S, et al. Cytotoxic effects of free fatty acids on ascites tumor cells. JNCI 1987; 78 (2): 271.

    Google Scholar 

  2. Gordon F, et al. Studies on thein vitro antitumor activity of fatty acids. I. 10-Hydroxy-2-decenoic acid from royal jelly. Cancer Res 1960; 20:503.

    Google Scholar 

  3. 1982;15:1.

  4. 1986; 13(1):75.

  5. Rivici E. Organic selenium compounds having an anti-neoplastic activity. Eur Pat Appl EP 95663 (CICO7CI 63/00), 07 Dec. 1983.

  6. 1988; 5(1):8.

  7. 1979;11:15.

  8. Marc E. Weksler, et al. Imparied lymphocyte function in aged humans. J Clin Invest 1974; 53:99.

    Article  PubMed  CAS  Google Scholar 

  9. Robert Lopez-Sandoval, et al.In vitro leukocyte thymidine uptake in chronic lymphocyte leukemia. Cancer Res. 1974; 34:146.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Dengshi, L., Zhixue, Y., Jinyi, T. et al. Studies on the antitumor activity of polyphase liposome of ricinoleic acid containing selenium. Chin J Cancer Res 3, 43–47 (1991).

Download citation

  • Issue Date:

  • DOI:

Key words