Abstract
The cytogenetics of HNE-1 cell line derived from the biopsy of nasopharyngeal carcinoma of a 27- year- old Chinese male has been investigated by chromosomal banding technique. A karyotypic characterization of subteraploid and a modal number of 74–77 have been revealed in this cell line. All cells contained a series of non- random chromosomal rearrangements. 18 of them, including 5 isochromosomes. were present in all metaphases and 3 of them in a few one. These findings indicated that the severe DNA damage and increase of gene copies may be occurred in genome of HNE-1 cells.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Laboratory of Tumor Viruses of Cancer Institute and Other Institutions in China. Establishment of an epithelial cell line and a fusoform cell line from a patient with nasopharyngeal carcinoma. Scientia Sinica 1978; 21:127.
Huang DP, et al. Establishment of a cell line (NPC/HK-1) from a differentiated squamous carcinoma of the nasopharyx. Int J Cancer 1980; 20:127.
Mitelman F. Chromosome patterns in human cancer and leukemia. In: Chromosomes and Cancer. New York. 1983; 61–83.
Finerty S, et al. Cytogenetics of malignant epithelial cells and lymphoblastoid cell line from nasopharyngeal carcinoma. Br J Cancer 1978.
Wu B, et al. Study of giant group A marker chromosome in several Burkitt’s lymphoma and lymphoblastoid cell lines with Epstein Barr Virus from different origins. Chinese Med J 1980; 93:400.
Zhang S, et al. Cytogenetic studies by chromosome banding techniques on peripheral blood cells from nasopharyngeal carcinoma patients. Chinese Med J 1980; 93:251.
de la Chapells A. How do human isochromosomes arise? Cancer Genet Cytogenet 1982; 5:173.
Atkin NB, Baker M. Small metacentric marker chromosomes, particularly isochromosomes, in cancer. Hum Genet 1988; 79:96.
Mitelman F. Restricted number of chromosomal regions implicated in aetiology of human cancer and leukemia. Nature 1984; 310:325.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Li, G., Yao, K. Cytogenetic study on a new epithelial cell line, HNE-1, derived from nasopharyngeal carcinoma. Chin J Cancer Res 3, 31–36 (1991). https://doi.org/10.1007/BF02997274
Issue Date:
DOI: https://doi.org/10.1007/BF02997274