Summary
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1.
A study was made of hypoglycemic reactions in 89 patients who had taken both regular and protamine zinc insulin for at least 6 months.
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2.
Fewer reactions occurred with protamine zinc insulin than with regular insulin.
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3.
Patients who had reactions with protamine zinc insulin reported them in general to be less severe and less frequent than with regular insulin.
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4.
Patients who were overweight were relatively free from reactions with protamine zinc insulin.
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5.
Hypoglycemic symptoms from protamine zinc insulin as described by 43 patients were listed in the order of their frequency.
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6.
Initial or warning symptoms of protamine zinc insulin shock were given in the order of frequency.
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7.
The prevention, recognition and treatment of protamine zinc insulin hypoglycemia were discussed.
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From the Metabolic Division of the Department of Medicine of the Henry Ford Hospital,
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Lowrie, W.L., Foster, D.P. Hypoglycemic reactions from protamine zinc insulin. American Journal of Digestive Diseases 7, 101–106 (1940). https://doi.org/10.1007/BF02997203
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DOI: https://doi.org/10.1007/BF02997203