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The effect of various antacids on the hydrogen-ion concentration of the gastric contents

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The American Journal of Digestive Diseases

Summary

The neutralizing influence of various commonly used antacids was investigated in a total of 290 experiments performed on 25 patients with healing duodenal ulcer. The hydrogen-ion concentration of the gastric contents removed hourly was determined by the glass electrode method. Control studies were made with a general diet and with hourly feedings of a three-ounce mixture of milk and cream. The alkalies were administered hourly; they included calcium carbonate and sodium bicarbonate in varying amounts, calcium carbonate alone, aluminum hydroxide, tricalsate, tribasic calcium phosphate, and magnesium trisilicate The effect of atropine on gastric acidity when given alone and in conjunction with various antacids, was also studied. Some of the results were compared with the results of 329 experiments in which the free HCl was determined by the usual titration method. Pertinent clinical and experimental reports are reviewed.

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References

  1. Dragstedt, L. R. and Vaughn, A. M.: Gastric Ulcer Studies.Arch. Surgery, 8:791, 1924.

    CAS  Google Scholar 

  2. Mann, F. C. and Williamson, C. S.: The Experimental Production of Peptic Ulcer.Ann. Surgery, 77:409, 1923.

    Article  CAS  Google Scholar 

  3. Palmer, W. L.: The Mechanism of Pain in Gastric and Duodenal Ulcers.Arch. Int. Med., 38:603, 694, 1923.

    Google Scholar 

  4. Friedenwald, J. and Morrison, S.: The Use of Gastric Antacids.J. A. M. A., 108:879, 1937.

    Google Scholar 

  5. Du Mesnil:Deutsche Med. Woch., 18:1112, 1892. Quoted by Crohn (12).

    Google Scholar 

  6. Linoissier and Lemoine:Bull. gen de therap., 127:492, 1894. Quoted by Crohn (12).

    Google Scholar 

  7. Bourget:Die Kranhheiten des Magens und Ihre Behandlung, p. 90, 1906. Quoted by Crohn (12).

  8. Bickel:Berlin Klin. Woch., xliii, 869, 1905. Quoted by Crohn (12).

  9. Lonnquist:Skand. Arch. f. Physiologic, 18:194, 1906,

    CAS  Google Scholar 

  10. Chiari:Therap. Monats. (Berlin), 29:202, 1915.

    Google Scholar 

  11. Pavlov, I. P.: The Work of the Digestive Glands. Philadelphia, J. B. Lippincott Co., 1910.

    Google Scholar 

  12. Crohn, B. B.: The Effect of Antacid Medication on Gastric Acidity and Secretion.Am. J. Med. Sci., 155:801, 1918.

    Google Scholar 

  13. Lockwood, B. C. and Chamberlin, H. G.: The Effect of Alkalies on Gastric Secretion and Motility as Measured by Fractional Gastric Analysis.Arch. Int. Med., 32:74, 1923.

    CAS  Google Scholar 

  14. Boyd, T. E.: Effect of Alkalies on Secretion and Composition of Gastric Juice.Am. J. Physiology, 71:455, 1925.

    CAS  Google Scholar 

  15. Keefer, C. S. and Bloomfield, A. L.: Quantitative Study of Effect of NaHC03 on Gastric Function.Bull. Johns Hopkins Hosp., 39:379, 1926.

    Google Scholar 

  16. Sippy, B. W.: Gastric and Duodenal Ulcer—Medical Cure by an Efficient Removal of Gastric Juice Corrosion.J. A. M. A., 64:1625, 1915.

    Google Scholar 

  17. Palmer, W. L.: Studies on the Neutralization of the Gastric Acidity in the Treatment of Peptic Ulcer.Trans. Am. Gastro- Ent. Assn., p. 123, 1932.

  18. Palmer, W. L.: Fundamental Difficulties in the Treatment of Ulcer.J. A. M. A., 101:1604, 1933.

    Google Scholar 

  19. Wosika, P. H. and Emery, E. S.: The Effectiveness of the Sippy Regime in Neutralizing the Gastric Juice of Patients if the Amount of Alkali is Not Varied.Ann. Int. Med., 9:1070, 1936.

    CAS  Google Scholar 

  20. Foldes, E.: The Physiology of Gastric Secretion.Klin. Woch., 3:1951, 1924.

    Article  Google Scholar 

  21. Michaelis, L.: Some Problems Concerning the Gastric Juice.Harvey Lectures, 21:59, 1926-27.

    Google Scholar 

  22. Helmer, D. M.: Personal communications to the authors.

  23. Martin, L.: Personal communications to the authors.

  24. Hollander, F.: Personal communications to the authors.

  25. Babkin, B. P.: The Physiological Factors Determining the Acidity of the Gastric Contents.Canadian M. Assn. J., 17:36, 1927.

    CAS  Google Scholar 

  26. Norgaard, A.: Colorimetric pH Determinations of Test Meal Filtrates in Patients with Gastric Diseases and Their Relation to Titration.Acta Medica Scandinavica, 60:498, 1924.

    CAS  Google Scholar 

  27. Freezer, C. R. E., Gibson, C. S. and Matthews, E.: A Contribution to the Study of Alkalies as Therapeutic Agents.Guy’s Hospital Reports, 78:191, 1928.

    Google Scholar 

  28. Alley, A.: The Effects on Gastric Secretion in Dogs of Various Food Substances Employed in the Treatment of Gastric Ulcer.Am. J. Dig. Dis. and Nutrit., 1:555, 1934.

    CAS  Google Scholar 

  29. Wosika, P. H. and Emery, E. S., {jrJr.}: The Value of a Mixture of Powdered Milk and Alkali for Neutralizing the Gastric Acidity of Patients with Peptic Ulcer.Ann. Int. Med., 9:1078, 1935-36.

    Google Scholar 

  30. Wosika, P. H.: The Control of Gastric Acidity in Peptic Ulcer by Alkalinized Powdered Skimmed Milk Tablets.Am. J. Med. Sci., 195:676, 1938.

    Article  CAS  Google Scholar 

  31. Boyd, T. E.: Influence of Alkalis on Secretion and Composition of Gastric Juice.Am. J. Physiol., 71:464, 1925.

    CAS  Google Scholar 

  32. Seckbach, M.: Influence of Neutralizing Substances on Hyperacid Gastric Juice.Deutsche Med. Woch., 52:233, 1926.

    Article  Google Scholar 

  33. Heinsheimer:Med. Klinik., ii:616, 1906.

    Google Scholar 

  34. Mayeda:Biochem. Ztschr., 2:332, 1907.

    CAS  Google Scholar 

  35. Loevenhart, A. S. and Crandall, L. A.: Calcium Carbonate in the Treatment of Gastric Hyperacidity Syndrome and in Gastric and Duodenal Ulcer.J. A. M. A., 88:1557, 1927.

    Google Scholar 

  36. Wosika, P. H.: The Control of Gastric Acidity in Peptic Ulcer by Alkalinized Powdered Whole Milk Tablets.Am. J. Dig. Dis. and Nutrit., 3:419, 1936.

    Google Scholar 

  37. Schellong: Favorable Results with Small Doses of Alkali and Belladonna in Gastric Hyperacidity.Munchen Med. Woch., 74: 1127, 1927.

    CAS  Google Scholar 

  38. Greenwald, I.: Gastric Antacids Which Cannot Act as Systemic Alkalis.Proc. Soc. Exper. Biol, and Med., 20:436, 1923.

    Google Scholar 

  39. Shattuck, H. F., Rohdenburg, E. L. and Booker, L. E.: Antacids in the Medical Management of Peptic Ulcer.J. A. M. A., 82:200, 1924.

    CAS  Google Scholar 

  40. Mutch, N.: The Silicates of Magnesium.Brit. Med. J., 1:143, 205, 254, 1936.

    Google Scholar 

  41. Mann, W. N.: Experiments on the Neutralization of NCI by Magnesium Trisilicate.Guy’s Hospital Reports, 87:151, 1937.

    CAS  Google Scholar 

  42. Kraemer, M.: The Use of Hydrated Trisilicate of Magnesium for Peptic Ulcer — Read before Section on Gastro-Enterology and Proctology at the Annual Meeting of the A. M. A., St. Louis, May, 1939.

  43. Reid, C. G.: The Control of Gastric Hyperacidity by Magnesium Trisilicate.Am. J. Dig. Dis., 6:267, June, 1939.

    CAS  Google Scholar 

  44. Guillermin, R.: Hyperchlorhydrie et hydrate ďalumine Colloidal.Rev. med de la Suisse Rom., 44:243, 1924.

    Google Scholar 

  45. Crohn, B. B.: The Clinical Use of Colloidal Aluminum Hydroxide as a Gastric Antacid.J. Lab. and Clin. Med., 14:610, 1929.

    CAS  Google Scholar 

  46. Einsel, I. H., Adams, W. L. and Meyers, V. C.: Aluminum Hydroxide in the Treatment of Peptic Ulcer.Am. J. Dig. Dis. and Nutrit., 1:513. 1934.

    CAS  Google Scholar 

  47. Woldman, E. E. and Rowland, V. C.: A New Technique for the Continuous Control of Acidity in Peptic Ulcer by the Aluminum Hydroxide Drip.Am. J. Dig. Dis. and Nutrit., 2:733, 1935.

    Google Scholar 

  48. Jones, C. R.: Colloidal Aluminum Hydroxide in Treatment of Peptic Ulcer.Am. J. Dig. Dis. and Nutrit., 4:99, 1937.

    CAS  Google Scholar 

  49. Rutherford. R. B. and Emery. E. S., {jrJr.}: The Clinical Effect of Colloidal Aluminum Hydroxide on Patients with Peptic Ulcer.N. England J. Med., 220:407, 1939.

    Article  Google Scholar 

  50. Bennett, T. I. and Gill, A. M.: Colloidal Aluminum Hydroxide in Treatment of Peptic Ulcer.Lancet,p. 500, March 4, 1939.

  51. Am. J. Dig. Dis. and Nutrit., 3:879, 1936.

  52. Adams, W. L.: A Critical Evaluation of Gastric Antacids.Arch. Int. Med., 63:1030, June, 1939.

    Google Scholar 

  53. Pavlov, I. P.: The Composition of Pure Gastric Juice.Am. J. Dig. Dis. and Nutrit., 1:319, 1934. Quoted by Hollander, F.

    Google Scholar 

  54. Bastedo, W. A.: Quoted by Friedenwald and Morrison (4).

  55. Keefer, C. S. and Bloomfield, A. L.: The Rate of Gastric Secretion in Man.J. Clin. Invest., 4:485, 1927.

    Article  PubMed  Google Scholar 

  56. Alvarez, W. C.: The Stomach and Duodenum. G. B. Eusterman, D. C. Balfour, W. B. Saunders Co., Philadelphia, p. 28, 1936.

    Google Scholar 

  57. Riegel, F.:Ztschr. F. Klin. Med., 37:381, 1899. Quoted by Keefer and Bloomfield (71).

    Google Scholar 

  58. von Bergmann:Munch. Med. Woch., 60:169, 1913. Quoted by Roberts (64).

    Google Scholar 

  59. Schmidt:J. A. M. A., 62:432, 1914.

    Google Scholar 

  60. Moore and Kilroe: Proc.Roy. Soc. Med., London, IV:2, Med. Section, 23:24, 1910–11. Quoted by Atkinson and Ivy (68).

  61. Kellerman, E.:Arch. F. Verdauungskr., 45:67, 1925. Quoted by Atkinson and Ivy (68).

    Google Scholar 

  62. Bennett, T. I.: Effect of Atropine and Pilocarpine on Secretion and Motility of Human Stomach.Guy’s Hospital Reports, 71:54, 1921.

    Google Scholar 

  63. Hernando, T.: Action of Drugs on Gastric Secretion.Presse Medicale. 31:797, 1923.

    Google Scholar 

  64. Roberts, W. M.: Action of Belladonna and Neutral Fats on Acidity of Stomach Contents.Qucrt. J. Med., 19:24, Oct., 1925.

    Google Scholar 

  65. Lockwood, B. C. and Chamberlin, H. G.: Effect of Atropine on Gastric Function as Measured by Fractional Analysis.Arch. Int. Med., 30:806, 1922.

    CAS  Google Scholar 

  66. Bastedo, W. A.: The Value of Atropine and Belladonna in Stomach Disorders.J. A. M. A., 106:85, 1936.

    CAS  Google Scholar 

  67. Porter, R. T.: Studies of the Effect of Atropine on Gastric Secretion.Proc. Soc. Exp. Biol. and Med., 29:504, 1932.

    CAS  Google Scholar 

  68. Atkinson, A. J. and Ivy, A. C.: Studies on the Control of Gastric Secretion. 1. Drugs Acting on the Autonomic Sympathetic System. 2. Drugs Acting as Central Emetics.Am. J. Dig. Dis. and Nutrit., 4:811, 1937.

    Google Scholar 

  69. Klumpp and Bowie, M. A.: Studies on Gastric Secretion.J. Clin. Invest., 12:1, 1933.

    Article  PubMed  CAS  Google Scholar 

  70. Polland, W. S.: The Effect of Atropine Upon Gastric Secretion After Histamine Stimulation.J. Clin. Invest., 9:319, 1930.

    Article  PubMed  CAS  Google Scholar 

  71. Keefer, C. S. and Bloomfield, A. L.: Effect of Atropine on Gastric Secretion in Man.Arch. Int. Med., 38:303, 1926.

    CAS  Google Scholar 

  72. Immerman, S. L.: Effect of Atropine on Gastric Contents of Man.J. Lab. and Clin. Med., 23:256, 1937.

    CAS  Google Scholar 

  73. Auer, J. and Meltzer, S. J.: Action of Ergot Upon Stomach and Intestines.Am. J. Physiol., 17:143, 1906.

    Google Scholar 

  74. Katsch, G.: Beitrage zum Studium der Darmbewegungen: Pharmakalogische Einplusse auf der Darm. (bei physiologischen Versuchsauardrung).Ztschr. F. Exp. Path. u. Therap., 12:253, 1912-13.

    Article  Google Scholar 

  75. Klee, P.: The Innervation of the Stomach.Deutsches Arch. F. Klin. Med., 133:265, 1920.

    Google Scholar 

  76. Otvos, W.: Reaction of Pylorus to Atropine.Deutsches Arch. F. Klin. Med., 136:58, 1921.

    Google Scholar 

  77. Stranz, J.: Diagnostic Use of Atropine Test of Stomach.Med. Klinik., 22:59, 1926.

    Google Scholar 

  78. McCrea, E. D. and MacDonald, A. D.: Action of Drugs Upon Movements of Stomach.Quart. J. Exper. Physiol., 19:161, 1928.

    Google Scholar 

  79. Lasch, C. H.: Effect of Atropine on Gastric Motility.Klin. Woch., 1:840, 1922.

    Article  CAS  Google Scholar 

  80. Herrin, R. C.: Effects of Atropine and Pilocarpine on Emptying Time of Human Stomach.Am. J. Physiol., 115:104, 1936.

    CAS  Google Scholar 

  81. Kalk, H. and Siebert, P.: Untersuchung uber der Wirkung von Atropin und. Belladonna auf die Magenfunktion.Arch. F. Verdauungskr., 40:313. 1922.

    Article  Google Scholar 

  82. Rall, T.: Uber den Einfluss der Atropin auf die Sekreturische und Motorische Funktion des gesunden Magens.Ztschr. f. d. des. Med., 52:752, 1926.

    Article  Google Scholar 

  83. Zung, E. and Tyesbaert, J.: Action of Atropine Sulphate on Isolated Stomach and Intestines.J. Pharm. and Exper. Therap., 8:325, 1916.

    Google Scholar 

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Authors and Affiliations

  1. Department of Medicine, University of Chicago, Chicago, Illinois

    Joseph b. Kirsner & Walter l. Palmer

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  1. Joseph b. Kirsner
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  2. Walter l. Palmer
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This study was supported in part by a grant from the John Wyeth & Brother Company, Philadelphia, Pa.

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Kirsner, J.b., Palmer, W.l. The effect of various antacids on the hydrogen-ion concentration of the gastric contents. American Journal of Digestive Diseases 7, 93–101 (1940). https://doi.org/10.1007/BF02997201

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  • DOI: https://doi.org/10.1007/BF02997201

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