Summary
Because of the frequency of gastric symptoms in diabetes insipidus, a study was made of the chemistry of the gastric juice in six patients with and without pituitrin injection and of the gastro-intestinal X-rays in four cases.
There was found in diabetes insipidus, changes in the chemistry of the gastric juice which may account for the gastric symptoms. These changes were characterized by a greater volume of gastric juice, a higher degree of acidity and an increased pepsin and rennin content than is ordinarily found in normal people. The administration of pituitrin decreased these findings.
Gastro-intestinal X-ray studies in four patients with marked gastric symptoms showed normal conditions in three cases while in the fourth case there was revealed a duodenal ulcer.
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Blotner, H.: Effect of Alcohol on Digestion by Gastric Juice, Trypsin and Pancreatin.J. A. M. A., 106: 1970, 1936.
Dodds, E. C., Noble, R. L., Scarf, R. W. and Williams, P. C.: Pituitary Control of Alimentary Blood Flow and Secretions. Changes Produced in Stomach by the Administration of Posterior Pituitary Extract.Proc. Roy. Soc., London, 123: 22, 1937.
Cutting, W. C., Dodds, E. C., Noble, R. L. and Williams, P. C.: The Effect of Posterior Pituitary Extract on the Alimentary Secretions of Intact Animals. Ibid., 123: 27, 1937.
Cutting, W. C., Dodds, E. C., Noble, R. L. and Williams, P. C.: Pituitary Control of Alimentary Blood Flow and Secretion. Gastric Secretion and Blood Flow in Hypophysectomized Animals. Ibid., 123: 49, 1937.
De Anciaes, C. J. H.: Insuline, Pituitrine et Secretion Gastrique.Compt. Rend. Soc. de Biol., 95: 313, 1926.
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From the Medical Clinic of the Peter Bent Brigham Hospital, Boston.
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Blotner, H. Gastric analyses and gastric symptoms in diabetes insipidus. American Journal of Digestive Diseases 7, 73–75 (1940). https://doi.org/10.1007/BF02997194
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DOI: https://doi.org/10.1007/BF02997194