Summary
The renal hemodynamic and tubular effects of S10036 (fotemustine) were evaluated in seven patients with advanced malignancy. Initial evaluation carried out prior to treatment and repeated 1 day after the first fotemustine infusion and 7 days after the second included clinical, haematological parameters, liver-function tests, and determination of the glomerular filtration rate, renal blood flow and enzymuria. The glomerular filtration rate was 108±3.7 ml/min before treatment and remained stable after the first (117±5 ml/min) and second (124±6 ml/min) fotemustine infusions. Renal blood flow and urinary β2-microglobulin andN’-acetylglucosaminidase excretion were also not modified by fotemustine administration. We conclude that fotemustine does not acutely alter renal haemodynamics, nor does it have direct tubular toxicity.
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Deray, G., Khayat, D., Jacquiaud, C. et al. Renal effects of S10036 in man. Cancer Chemother Pharmacol 26, 467–468 (1990). https://doi.org/10.1007/BF02994102
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DOI: https://doi.org/10.1007/BF02994102