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Detection of neutrophil inhibition factor (NIF) in patient with carcinoma of larynx using skin-window technique

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Abstract

Tumour antigen-induced leucocyte inhibition was studied in vivo in patients with laryngeal carcinomas (squamous-cell type in 13 and transitional cell type in 1 case) and benign tumours (squamous cell papilloma in 2, fibroepithelial polyp in 1 and mixed mesenchymal tumour in 1 case). All the patients were biopsied and autologous tumour-antigen (ATA) was used in vivo skin window test.

Release of of ATA-induced neutrophil inhibition factor (NIF) was detected in 12 of 14 (85.7%) malignant cases. Basophilic chemotaxis occurred in 4 malignant cases, following exposure to ATA. Furthermore, 4 other malignant cases also gave positive ATA-induced delayed hypersensitivity (DH) response. Results of this study suggest possible role of immunological factors in limiting tumour dissemination.

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Authors and Affiliations

  1. Department of Pathology, K. G. Medical College, Lucknow

    A. K. Kapoor

  2. Department of Otorhinolaryngology, K. G. Medical College, Lucknow

    H. Sharma, D. Dayal & S. P. Agarwal

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  1. A. K. Kapoor
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  2. H. Sharma
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  3. D. Dayal
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  4. S. P. Agarwal
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Kapoor, A.K., Sharma, H., Dayal, D. et al. Detection of neutrophil inhibition factor (NIF) in patient with carcinoma of larynx using skin-window technique. Indian J Otolaryngol 41, 16–18 (1989). https://doi.org/10.1007/BF02994032

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