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International Journal of Hematology

, Volume 73, Issue 4, pp 416–428 | Cite as

The Role of Apoptosis in the Pathogenesis of the Myelodysplastic Syndromes

  • Jane E. Parker
  • Ghulam J. Mufti
Progress in hematology

Abstract

The paradoxical occurrence of peripheral cytopenias despite a normo/hypercellular marrow in myelodysplastic syndromes (MDS) has been attributed to excessive intramedullary hematopoietic cell apoptosis. It has also been postulated that abrogation of programmed cell death (PCD) may underlie MDS transformation to acute myeloid leukemia (AML). Despite overwhelming evidence for a role of aberrant apoptosis in myelodysplasia, the molecular mechanisms responsible for such changes have not been elucidated. This paper summarizes current evidence implicating a role for altered PCD in MDS and outlines potential cellular mechanisms whereby hematopoietic progenitor cell apoptosis may be dysregulated.

Key words

Apoptosis MDS AML Fas Bcl-2 

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Copyright information

© The Japanese Society of Hematology 2001

Authors and Affiliations

  1. 1.The Department of Haematological MedicineGuy’s, King’s, Thomas’ School of MedicineLondonUK

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