Abstract
Our previous reports have shown that animals inoculated for 8 weeks with 1 × 105 pseudohyphal, avirulentC. neoformans exhibited prolonged survival upon challenge with virulent cryptococci. This paper described a transient phase of immunosuppression which occurs during the initial weeks of the immunization protocol. Animals injected with pseudohyphal organisms had depressed responses to T and B-cell mitogens. In addition, they had lowered responses to immunization with sheep erythrocytes. Both humoral and cell mediated responses were affected.
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Blackstock, R., Hall, N.K. Immunosuppression by avirulent, pseudohyphal forms ofCryptococcus neoformans . Mycopathologia 80, 95–99 (1982). https://doi.org/10.1007/BF02993850
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DOI: https://doi.org/10.1007/BF02993850