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Antimycobacterial activity of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids

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Abstract

A series of 17 hydrochlorides of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids with the alkoxy group in position 2, 3 or 4 on the phenyl ring, and basic substituents attached to the moiety in position 3, were evaluated forin vitro antimycobacterial activity against the strains ofMycobacterium tuberculosis, M. kansasii andM. avium. To describe the structure-antimycobacterial activity relationships (QSAR), an approach based on the Free-Wilson method was employed to express the differences between individual moieties (including propyl and ethyl). The change of ethyl to propyl moiety increases the activity toM. tuberculosis but decreases the antimycobacterial activity to all potentially pathogenic strains under study.

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References

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Authors and Affiliations

  1. Department of Inorganic and Organic Chemistry, Charles University, Faculty of Pharmacy, 500 05, Hradec Králové, Czechia

    K. Waisser & K. Dražková

  2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, 832 32, Bratislava, Slovakia

    J. Čižmárik

  3. Department for Diagnostics of Mycobacteria, Regional Institute of Public Health, Ostrava, 728 92, Ostrava, Czechia

    J. Kaustová

Authors
  1. K. Waisser
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  2. K. Dražková
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  3. J. Čižmárik
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  4. J. Kaustová
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Additional information

This work was supported by theMinistry of Education, Youth and Sports of the Czech Republic (project no. MSM 111 600 001) and by projectKONTAKT (78/ČR, 237/SR)

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Waisser, K., Dražková, K., Čižmárik, J. et al. Antimycobacterial activity of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids. Folia Microbiol 48, 585–587 (2003). https://doi.org/10.1007/BF02993463

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  • DOI: https://doi.org/10.1007/BF02993463

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