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Regional cyclophosphamide chemotherapy in advanced carcinoma maxilla

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Abstract

14 patients of advanced carcinoma maxilla who presented to the Medical College Hospital, Aurangabad, were treated by intra-arterial cyclophosphamide chemotherapy. Two dosage regime of 200 mg. per day and 500 mg. per day were used either continuously or intermittently. Regression of tumour was obtained in only two cases and regression in size of lymph nodes in another two cases. Subjective improvement in form of feeling of well-being was obtained in two cases. In the other eight cases there was no effect on tumour. Neurological complications experienced were hemiplegia in two cases and transient paresis in two cases.

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References

  1. Bierman, H. R., Byron, R. L. Jr., Miller, S. R. and Shimkin, M. B. (1950), Effect of intra-arterial administration of Nitrogen-Mustard.American Journal of Medicine,8: 535.

    Article  PubMed  CAS  Google Scholar 

  2. Calabresi, and Park (1970). In Pharmacological Basis of Therapeutics, Goodman, L. S. and Gillman, Alfred Ed. 4th edition, London, Macmillan Co., page 1356.

    Google Scholar 

  3. Donegan, W. L. (1975). Regional perfusion chemotherapy for Cancer of Head and Neck.Surgery Annual Nyhus, L. M. Ed., page 137.

  4. Epsinar, H. J. (1968). The Rational and Development of a method of regional chemotherapy in Cancer of Head and Neck.British Journal of Plastic Surgery,21: 94.

    Article  Google Scholar 

  5. Harrison, D. F. N. (1965). Clinical experience of chemotherapy.Archives of Otolaryngology,81: 175.

    PubMed  CAS  Google Scholar 

  6. Jesse, R. H., Villareal, R., Ruffino, C. and Kikey, R. C. (1964). Intra-arterial infusion of Head and Neck Cancers.Archives Of Surgery,88: 618.

    PubMed  CAS  Google Scholar 

  7. Klopp, C. T., Alford, T. C., Bataman, J., Berry, G. M. and Winship, T. (1962). Fractionated intra-arterial Cancer chemotherapy with Bis-amino hydrochloride, as preliminary report.Annals Of Surgery,132: 811.

    Article  Google Scholar 

  8. Nervi, C., Areageli, G. and Casale, C. (1977). Reappraisal of Chemotherapy.Cancer,26: 577.

    Article  Google Scholar 

  9. Oberfield, R. A., Cady, B. and Booth, J. C. (1973). Regional arterial chemotherapy for advanced carcinoma of Head and Neck, 10 years review.Cancer,32: 82.

    Article  PubMed  CAS  Google Scholar 

  10. Satoskar, Kale and Bhandarkar (1973). Pharmachology and Pharmacotherapeutics, Poona., Popular Prakashan, page 593.

    Google Scholar 

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Author notes

  1. Arun V. Jamkar

    Present address: S. R. T. R. Medical College, Ambajogai

Authors and Affiliations

  1. Medical College, Aurangabad

    Arun V. Jamkar, R. S. Kanchan & A. G. Rege

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  1. Arun V. Jamkar
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  2. R. S. Kanchan
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  3. A. G. Rege
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Jamkar, A.V., Kanchan, R.S. & Rege, A.G. Regional cyclophosphamide chemotherapy in advanced carcinoma maxilla. Indian J Otolaryngol 31, 11–13 (1979). https://doi.org/10.1007/BF02992243

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