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Interactions of food antigens, antibodies, and antigen-antibody complexes in health and disease

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References

  1. Bienenstock J, Befus AD: Mucosal immunology. Immunology 41:249–270, 1980

    PubMed  CAS  Google Scholar 

  2. Ganguly R, Waldman RH: Local immunity and local immune responses. Prog Allergy 27:1–68, 1980

    PubMed  CAS  Google Scholar 

  3. Bazin H: The secretory antibody system, in Ferguson A, McSween RNM (eds): Immunological Aspects of the Liver and Gastrointestinal Tract. MTP, Lancaster, pp 33–82, 1976

    Google Scholar 

  4. Mestecky J, Lawton AR (eds): The immunoglobulin A system. Plenum Press, New York, 1974

    Google Scholar 

  5. Lamm ME: Cellular aspects of immunoglobulin A. Adv Immunol 22:223–290, 1976

    Article  PubMed  CAS  Google Scholar 

  6. Elson CO, Heck JA, Straber W: T cell regulation of murine IgA synthesis. J Exp Med 127:632–639, 1979

    Article  Google Scholar 

  7. Walker WA, Isselbacher KJ: Uptake and transport of macromolecules by the intestine: possible role in clinical disorders. Gastroenterology67:531–550, 1974

    PubMed  CAS  Google Scholar 

  8. Kilshaw PJ, Slade H: Passage of ingested protein into the blood during gastrointestinal hypersensitivity reactions: experiments in the preruminant calf. Clin Exp Immunol 41:575–582, 1980

    PubMed  CAS  Google Scholar 

  9. Paganelli R, Levinsky RJ, Brostoff J, Wraith DG: Immune complexes containing food proteins in normal and atopic subjects after oral challenge, and effect of sodium cromoglycate on antigen absorption. Lancet 1:1270–1272, 1979

    Article  PubMed  CAS  Google Scholar 

  10. Dannaeus A, Inganas M, Johansson SGO, Foucard T: Intestinal uptake of ovalbumin in malabsorption and food allergy in relation to serum IgG antibody and orally administered sodium cromoglycate. Clin Allergy 9:263–270, 1979

    Article  PubMed  CAS  Google Scholar 

  11. Jarrett EEE: Activation of IgE regulatory mechanisms by transmucosal absorption of antigen. Lancet 11:223–225, 1977

    Article  Google Scholar 

  12. Lafont S, André C, André F, Gillon J, Fargier MC: Abrogation by subsequent feeding of antibody response, including IgE, in parenterally immunized mice. J Exp Med 155:1573–1578, 1982

    Article  PubMed  CAS  Google Scholar 

  13. Roberts SA, Reinhardt MC, Paganelli R, Levinsky RJ: Specific antigen exclusion and nonspecific facilitation of antigen entry across the gut in rats allergic to food proteins. Clin Exp Immunol 45:131–136, 1981

    PubMed  CAS  Google Scholar 

  14. May CD, Remigio L, Feldman J, Bock SA, Carr RI: A study of serum antibodies to isolated milk proteins and ovalbumin in infants and children. Clin Allergy 7:583–595, 1977

    Article  PubMed  CAS  Google Scholar 

  15. Brostoff J, Challacombe SJ (eds): Food Allergy. Clinics in Immunology and Allergy, Vol 2, N 1, London, W.B. Saunders, 1982

    Google Scholar 

  16. Chase MW: Inhibition of experimental drug allergy by prior feeding of the sensitizing agent. Proc Soc Exp Biol Med 61:257–259, 1946

    CAS  Google Scholar 

  17. Tornasi TB: Oral tolerance. Transplantation 29:353–356, 1980

    Google Scholar 

  18. Challacombe SJ, Tornasi TB: Systemic tolerance and secretory immunity after oral immunization. J Exp Med 152:1459–1472, 1980

    Article  PubMed  CAS  Google Scholar 

  19. Hanson LA, Ahlstedt S, Carlsson B, Fällstrom SP: Secretory IgA antibodies against cow’s milk proteins in human milk and their possible effect in mixed feeding. Int Arch Allergy Appl Immunol 54:457–462, 1977

    PubMed  CAS  Google Scholar 

  20. Roberts SA, Soothill JF: Provocation of allergic response by supplementary feeds of cow’s milk. Arch Dis Child 57:127, 1982

    PubMed  CAS  Google Scholar 

  21. Jarrett EEE, Hall E: Selective suppression of IgE antibody responsiveness by maternal influence. Nature 280:145–146, 1979

    Article  PubMed  CAS  Google Scholar 

  22. Abrahamson DR, Powers A, Rodewald R: Intestinal absorption of immune complexes by neonatal rats: a route of antigen transfer from mother to young. Science 206:567–569, 1979

    Article  PubMed  CAS  Google Scholar 

  23. Kiyono H, McGhee JR, Wannemuehler MJ, Michalek SM: Lack of oral tolerance in C3H/HeJ mice. J Exp Med 155:605–610, 1982

    Article  PubMed  CAS  Google Scholar 

  24. Freed DLJ: Laboratory diagnosis of food intolerance, in Brostoff J, Challacombe SJ (eds): Food Allergy. Clinics in Immunology and Allergy Vol 2, No 1. London, W.B. Saunders, pp 181–203, 1982

    Google Scholar 

  25. Buckley RH, Dees SC: Correlation of milk precipitins with IgA deficiency. N Engl J Med 281:465–469, 1969

    PubMed  CAS  Google Scholar 

  26. Wide L, Bennich H, Johansson SGO: Diagnosis of allergy by an in vitro test for allergen antibody. Lancet 11:1105–1107, 1967

    Article  Google Scholar 

  27. Turner MW, Paganelli R, Levinsky RJ, Williams A: Antigen-binding radioimmunoassays for human IgG antibodies to bovine β-lactoglobulin. J Immunol Methods 56:175–183, 1983

    Article  PubMed  CAS  Google Scholar 

  28. Paganelli R, Levinsky RJ: Differences in specific antibody responses of human tonsillar cells to an oral and a parenteral antigen. Scand J Immunol 14:353–358, 1981

    Article  PubMed  CAS  Google Scholar 

  29. Stokes CR, Swarbrick ET, Soothill JF: Immune elimination and enhanced antibody responses: functions of circulating IgA. Immunology 40:455–458, 1980

    PubMed  CAS  Google Scholar 

  30. Stokes CR, Soothill JF, Turner MW: Immune exclusion is a function of IgA. Nature 255:745, 1975

    Article  PubMed  CAS  Google Scholar 

  31. Williams RC, Gibbons RJ: Inhibition of bacterial adherence by secretory immunoglobulin A. A mechanism of antigen disposal. Science 177:395–399, 1972

    Article  Google Scholar 

  32. Ogra PL, Karzon DT, Righthand F, McGillivary M: Immunoglobulin response in serum and secretions after immunization with live and inactivated polio vaccine and natural infection. N Engl J Med 279:893–396, 1968

    Article  CAS  PubMed  Google Scholar 

  33. Orlans E, Peppard J, Reynolds J, Hall J: Rapid active transport of immunoglobulin A from blood to bile. J Exp Med 147:588–592, 1978

    Article  PubMed  CAS  Google Scholar 

  34. Levinsky RJ, Paganelli R, Roberton DM, Atherton DJ: Handling of food antigens and their complexes by normal and allergic individuals, in Wilkinson AW (ed): The Immunology of Infant Feeding. Plenum Press, New York, pp 23–31, 1981

    Google Scholar 

  35. Paganelli R, Levinsky RJ: Solid phase radioimmunoassay for detection of circulating food protein antigens in human serum. J Immunol Methods 37:333–341, 1980

    Article  PubMed  CAS  Google Scholar 

  36. Paganelli R, Levinsky RJ, Atherton DJ: Detection of specific antigen within circulating immune complexes. Validation of the assay and its application to food antigen-antibody complexes found in healthy and food allergic subjects. Clin Exp Immunol 46:44–53, 1981

    PubMed  CAS  Google Scholar 

  37. Warner JO: Food allergy in fully breast fed infants. Clin Allergy 10:133, 1980

    Article  PubMed  CAS  Google Scholar 

  38. Rieger CHL, Rothberg RM: Development of the capacity to produce specific antibody to an ingested food antigen in the premature infant. J Pediatr 87:515–518, 1975

    Article  PubMed  CAS  Google Scholar 

  39. Roberton DM, Paganelli R, Dinwiddie R, Levinsky RJ: Milk antigen absorption in the preterm and term neonate. Arch Dis Child 57:369–372, 1982

    Article  PubMed  CAS  Google Scholar 

  40. Walker WA: Gastrointestinal host defense: importance of gut closure in control of macro-molecular transport, in Ciba Found Symp 70: Development of mammalian absorptive processes. Excerpta Medica, Amsterdam, pp 201–216, 1979

    Google Scholar 

  41. Delire M, Cambiaso CL, Masson PL: Circulating immune complexes in infants fed on cow’s milk. Nature 272:632, 1978

    Article  PubMed  CAS  Google Scholar 

  42. D’Amelio R, Seminara R, Galli E, Antoniazzi G, Businco L, Aiuti F: Circulating immune complexes in infants fed on cow’s milk. Nature 298:72, 1982

    Article  PubMed  CAS  Google Scholar 

  43. Cunningham-Rundles C, Brandeis WE, Good RA: Bovine antigens and the formation of circulating immune complexes in selective IgA deficiency. J Clin Invest 64:272–279, 1979

    Article  PubMed  CAS  Google Scholar 

  44. Cunningham-Rundles C: Naturally occurring autologous anti-idiotypic antibodies. Participation in immune complex formation in selective IgA deficiency. J Exp Med 155:711–719, 1982

    Article  PubMed  CAS  Google Scholar 

  45. Chandra RK: Food antibodies in malnutrition. Arch Dis Child 50:532–534, 1975

    PubMed  CAS  Google Scholar 

  46. Reinhardt MC, Paganelli R, Levinsky RJ: Intestinal antigen handling at mucosal surfaces in health and disease: human and experimental studies. Ann Allergy (in press)

  47. Gruskay FL, Cooke RE: The gastrointestinal absorption of unaltered protein in normal infants and in infants recovering from diarrhoea. Pediatrics 16:763–768, 1955

    PubMed  CAS  Google Scholar 

  48. Dannaeus A, Johansson SGO, Foucard T, Ohman S: Clinical and immunological aspects of food allergy in childhood. I. Estimation of IgG, IgA and IgE antibodies to food antigens in children with food allergy and atopic dermatitis. Acta Pediatr Scand 66:31–37, 1977

    Article  CAS  Google Scholar 

  49. Platts-Mills TAE, Snajdr MJ, Ishizaka K, Frankland AW: Measurement of IgE antibody by an antigen-binding assay: correlation with PK activity and IgG and IgA antibodies to allergens. J Immunol 120:1201–1210, 1978

    PubMed  CAS  Google Scholar 

  50. Jackson PG, Lessof MH, Baker RWR, Ferrett J, McDonald DM: Intestinal permeability in patients with eczema and food allergy. Lancet 1:1285–1286, 1981

    Article  PubMed  CAS  Google Scholar 

  51. Brostoff J, Carini C, Wraith DG, Paganelli R, Levinsky RJ: Immune complexes in atopy, in Pepys J, Edwards AM (eds): The Mast Cell—Its Role in Health and Disease. Pitman, London, pp 380–393, 1979

    Google Scholar 

  52. Inganas S, Johansson SGO, Dannaeus A: A method for estimation of circulating immune complexes after oral challenge with ovalbumin. Clin Allergy 10:293–302, 1980

    Article  PubMed  CAS  Google Scholar 

  53. André C, Heremans JF, Vaerman JP, Cambiaso CL: A mechanism for the induction of immunological tolerance: antigen-antibody complexes. J Exp Med 142:1509–1519, 1975

    Article  PubMed  Google Scholar 

  54. Chalon MP, Milne RW, Vaerman JP: In vitro immunosuppressive effect of serum from orally immunized mice. Eur J Immunol 9:747–750, 1979

    Article  PubMed  CAS  Google Scholar 

  55. Mattingly JA, Kaplan JM, Janeway CR Jr: Two distinct antigen-specific suppressor factors induced by the oral administration of antigen. J Exp Med 152:545–553, 1980

    Article  PubMed  CAS  Google Scholar 

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Studies reported in this paper were partly funded by the University of Rome. Dr. Paganelli was supported by the Nuffield Foundation and Serono Institute.

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Paganelli, R., Matricardi, P.M. & Aiuti, F. Interactions of food antigens, antibodies, and antigen-antibody complexes in health and disease. Clin Rev Allerg 2, 69–78 (1984). https://doi.org/10.1007/BF02991212

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