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Immunochemical aspects of human IgG4

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References

  1. Gergely J, Stanworth DR, Jefferis R, Normansell DE, Henney CS, Pardoes I: Structural studies of immunoglobulins. I. The role of cysteine in papain hydrolysis. Immunochemistry 4:101, 1967

    Article  CAS  Google Scholar 

  2. Gergely J, Medgyesi GA, Stanworth DR: Structural studies of immunoglobulins. II. The varying susceptibility to papain-digestion of a group of human myeloma γ-globulins. Immunochemistry 4:369, 1967

    Article  CAS  Google Scholar 

  3. Jefferis R, Weston PD, Stanworth DR, Clamp JR: Relationship between the papain sensitivity of human immunoglobulins and their heavy chain subclass. Nature (London) 219:646, 1968

    Article  CAS  Google Scholar 

  4. Shakib F, Stanworth DR: Human IgG subclasses in health and disease. I. La Ricerca in Clinica e Laboratorio 10:463 1980: II. La Ricerca in Clinica e Laboratorio 10:561 1980

    Article  CAS  Google Scholar 

  5. Shakib F, Stanworth DR, Drew R, Catty D: A quantitative study of the distribution of IgG subclasses in a group of normal human sera. J Immunol Meth 8:17, 1975

    Article  CAS  Google Scholar 

  6. Stanworth DR: Immunoglobulinopathies, in Glynn LE, Steward MW (eds): Antibody Production. New York, Wiley, 1981, chap 4

    Google Scholar 

  7. Morell A, Skvaril F, Hitzig WH, Barandum S: IgG subclasses development of the serum concentration in normal infants and children. J Pediat 80:960, 1972

    Article  PubMed  CAS  Google Scholar 

  8. Van Der Giessen M, Rossouw E, Algra-Van Veen T, Van Loghem E, Zegers BJ, Sanders PC: Quantification of IgG subclasses in sera of normal adults and healthy children between 4 and 12 years of age. Clin Exp Immunol 21:501, 1975

    PubMed  Google Scholar 

  9. Shakib F, Stanworth DR: IgG subclass composition of rheumatoid arthritic sera and joint fluids. Ann Rheum Dis 35:263, 1976

    Article  PubMed  CAS  Google Scholar 

  10. Palmer DL, Mirard BJ, Cawley LP: IgG subgroups in cerebrospinal fluid in multiple sclerosis. N Engl J Med 294:447, 1976

    PubMed  CAS  Google Scholar 

  11. Vandvik B, Natvig JB, Wiger D: IgG1 subclass restriction of oligoclonal IgG from cerebrospinal fluids and brain extracts in patients with multiple sclerosis and subacute encephalitides. Scand J Immunol 5:427, 1976

    Article  PubMed  CAS  Google Scholar 

  12. Johns P, Marriott T, Stanworth DR: An improved method of predicting immunoglobulin conformation with particular reference to IgG. In preparation. 1982

  13. Kunkel HG, Joslin FG, Penn GM, Natvig JB: Generic variants of γG4 globulin. A unique relationship to other classes of γG globulin. J Exp Med 132:508, 1970

    Article  PubMed  CAS  Google Scholar 

  14. Stanworth DR: Immediate Hypersensitivity: The Molecular Basis of the Allergic Response. Vol 28, North Holland Research Monographs: Frontiers of Biology. Amsterdam, North Holland, 1973

    Google Scholar 

  15. Ishizaka T, Ishizaka K, Salmon S, Fudenberg HH: Biologic activities of aggregated γ-globulin. VIII. Aggregated immunoglobulin of different classes. J Immunol 99:82, 1967

    PubMed  CAS  Google Scholar 

  16. Huber H, Fudenberg HH: Receptor sites of human monocytes for IgG1. Int Arch Allergy 34:18, 1968

    PubMed  CAS  Google Scholar 

  17. Hay FC, Torrigiani G, Roitt IM: The binding of human IgG subclasses to human monocytes. Eur J Immunol 2:257, 1972

    Article  PubMed  CAS  Google Scholar 

  18. Lawrence DA, Weigle WO, Spiegelberg HL: Immunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils. J Clin Invest 55:368, 1975

    Article  PubMed  CAS  Google Scholar 

  19. Ovary Z, Benacerraf B, and Bloch KJ: Properties of guinea pig 7S antibodies. II. Identification of antibodies involved in passive cutaneous and systemic anaphylaxis. J Exp Med 140:193, 1963

    CAS  Google Scholar 

  20. Reid R, Minden P, Farr RS: Reaginic activity associated with IgG immunoglobulin. J Exp Med 123:845, 1966

    Article  PubMed  CAS  Google Scholar 

  21. Parish WE: Short term anaphylactic IgG antibodies in human sera. The Lancet ii:591, 1970

    Article  Google Scholar 

  22. Goodwin BFJ: Nonreaginic anaphylactic antibodies in man. Clin Rev Allergy 2:249–258, 1983

    Google Scholar 

  23. Bryant DH, Burns MW, Lazarus L: New type of allergic asthma due to IgG “reaginic” antibody. Br Med J 4:589, 1973

    Article  PubMed  CAS  Google Scholar 

  24. Stanworth DR, Smith AK: Inhibition of reagin-mediated PCA reaction in baboons by the human IgG4 subclass. Clin Allergy 1:37, 1973

    Google Scholar 

  25. Stanworth DR, Humphrey JH, Bennich H, Johansson SGO: Specific inhibition of the Prausnitz-Kustner reaction by an atypical human myeloma protein. The Lancet ii:330, 1967

    Article  Google Scholar 

  26. Nakagawa T, de Week AL: Membrane receptors for the IgG4 subclass on human basophils and mast cells. Clin Rev Allergy 2:197–206, 1983

    Google Scholar 

  27. Vijay A and Perelmutter L: Inhibition of reagin-mediated PCA reactions in monkeys and histamine release from human leukocytes by human IgG4 subclass. Int Arch Allergy Appl Immunol 53:78, 1977

    PubMed  CAS  Google Scholar 

  28. Van Toorenenbergen AW, Aalberse RC: IgG4 and passive sensitization of basophil leukocytes. Int Arch Allergy Appl Immunol 65:432, 1981

    PubMed  Google Scholar 

  29. Van Toorenenbergen AW, Aalberse RC: IgG4 release of histamine from human peripheral blood leukocytes. Int Arch Allergy Appl Immunol 67:117, 1982

    PubMed  Google Scholar 

  30. Malley A, Beacher L, Porter G, Gerding R: Competitive inhibition of reagin-mediated histamine release by a human IgG2 myeloma protein. Int Arch Allergy Appl Immunol 47:194, 1974

    PubMed  CAS  Google Scholar 

  31. Shakib F, McLaughlan P, Stanworth DR, Smith E, Fairburn E: Elevated serum IgE and IgG4 in patients with atopic dermatitis. Br J Dermatol 97:59, 1977

    Article  PubMed  CAS  Google Scholar 

  32. Shakib F, Stanworth DR, Smalley CA, Brown GA: Elevated serum IgG4 levels in cystic fibrosis patients. Clin Allergy 6:237, 1976

    Article  PubMed  CAS  Google Scholar 

  33. Gwynn CM, Morrison Smith J, Leon Leon G, Stanworth DR: Role of IgG4 subclass in childhood allergy. The Lancet i:910, 1978

    Article  Google Scholar 

  34. Gwynn CM, Morrison Smith J, Leon Leon G, Stanworth DR: IgE and IgG4 subclass in atopic families. Clin Allergy 9:119, 1979

    Article  PubMed  CAS  Google Scholar 

  35. Gwynn CM, Ingram J, Almosawi T, Stanworth DR: Bronchial provocation tests in atopic-patients with allergen specific IgG4 antibodies. The Lancet i:254, 1982

    Article  Google Scholar 

  36. Almosawi T, Gwynn CM, Stanworth DR: Incidence of STS IgG antibody in atopic individuals and their relation to specific IgG4 antibodies. In preparation. 1982

  37. Nelson HS, Branch LB: Incidence of IgG short term sensitising antibodies in the allergic population. J Allergy Clin Immunol 60:266, 1977

    Article  PubMed  CAS  Google Scholar 

  38. McLaughlan P: In vitro and in vivo studies with radiolabelled IgE and anti-IgE. University of Birmingham, Ph.D. thesis, 1973

  39. McLaughlan P, Stanworth DR: IgG4 antibody responses of grass pollen sensitive individuals as a result of hyposensitisation, in Proceedings of the Second International Immunology Congress, Brighton, 1974

  40. Van Der Giessen M, Homan WL, Kernebeek G Van, Aalberse RC, Dieges PH: Subclass typing of IgG antibodies formed by grass pollen allergic patients during immunotherapy. Int Arch Allergy Appl Immunol 50:625, 1976

    PubMed  Google Scholar 

  41. Devey ME, Panzani R: The IgG subclasses of antibodies to castor bean allergen in patients with allergic asthma: Detection of a high incidence of antibodies of the IgG4 subclass. Clin Allergy 5:353, 1975

    Article  PubMed  CAS  Google Scholar 

  42. Shakib F, Stanworth DR: IgG4: a possible mediator of anaphylaxis in a haemophiliac patient. Clin Allergy 9:597, 1979

    Article  PubMed  CAS  Google Scholar 

  43. Sehon AH, Hollinger HZ, Harter JG, Schweitzer AE, Rose B: Localization of blocking antibody in sera of ragweed-sensitive individuals by starch electrophoresis. J Allergy 28:229, 1957

    Article  PubMed  CAS  Google Scholar 

  44. Aalberse RC, Van Leeuwen J: The role of IgG, as allergen blocking antibody. Abstract 13.1.01. 4th International Congress of Immunology, Paris, 1980

  45. Devey ME, Wilson DV, Wheeler AW: The IgG subclasses of antibodies to grass pollen allergens produced in hay fever patients during hyposensitisation. Clin Allergy 6:227, 1976

    Article  PubMed  CAS  Google Scholar 

  46. Bruynzeel PLB, Berrens L: IgE and IgG, antibodies in specific human allergies. Int Arch Allergy Appl Immunol 58:344, 1979

    PubMed  CAS  Google Scholar 

  47. Stanworth DR, Turner MW: Immunochemical analysis of immunoglobulins and their sub-units, in: Weir DM (ed): Handbook of Experimental Immunology, 3rd ed. Oxford, Blackwell, 1978, chap 6

    Google Scholar 

  48. Fagan DL, Slaughter CA, Capra JD, Sullivan J: Monoclonal antibodies to IgG4 induced histamine release from human basophils in vitro. J All Clin Immunol 70:399, 1982

    Article  CAS  Google Scholar 

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  1. Rheumatology and Allergy Research Unit, Department of Immunology, University of Birmingham, B15 2TJ, Birmingham, UK

    D. R. Stanworth

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Stanworth, D.R. Immunochemical aspects of human IgG4 . Clin Rev Allerg 1, 183–195 (1983). https://doi.org/10.1007/BF02991153

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