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Rhabdomyolysis: An unusual complication of cytotoxic chemotherapy

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Acute rhabdomyolysis has rarely been reported after cytotoxic chemotherapy, including cytarabine and 5-azacytidine. We observed a case of acute rhabdomyolysis and renal failure after treatment with mitoxantrone and cyclophosphamide. No other cause of muscle injury could be identified, although biochemical analysis of a muscle biopsy specimen revealed a deficiency of muscle phosphorylase activity. Retreatment with doxorubicin and paclitaxel was not associated with recurrent rhabdomyolysis.

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Levy, R.J., Sparano, J.A. & Khan, G. Rhabdomyolysis: An unusual complication of cytotoxic chemotherapy. Med Oncol 12, 219–222 (1995).

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