Abstract
The effect of an excessive inorganic silicon oral intake on the activity of basic antioxidant enzymes was studied in rats. Activities of superoxide dismutase, catalase, and glutathione peroxidase were measured in liver and kidney tissues of animals receiving per os sodium metasilicate nonahydrate (Na2SiO3.9H2O) (Sigma, [St. Louis, MO]) dissolved in their drinking water. A decrease of the activity of all the studied enzymes was found in the samples derived from the experimental group. The results obtained indicate the free oxygen radicals participation in the potential pathologic events in the conditions of systemic hypersilicemia.
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J. D. Birchall, in Williams, R. J. P. and Da Silva, R. R., eds.,New Trends in Inorganic Chemistry, Academic, London, 1978, pp. 209–252.
L. M. Holland,Regul. Toxicol. Pharmacol. 12, 224–237 (1990).
J. W. Dobbie and M. J. B. Smith,Scott. Med. 27, 17–19 (1982).
J. A. Last and K. M. Reiser, inSilicon Biochemistry, Evered, D., ed., Ciba Found. Symp. 121, Wiley, Chichester, 1986, pp. 180–187.
K. M. Reiser, W. M. Haschek, T. Hesterberg, and J. A. Last,Am. J. Pathol. 110, 30–41 (1983).
K. M. Reiser and J. A. Last,Toxicology 13, 51–72 (1979).
K. Schwarz, inBiochemistry of Silicon and Related Problems, Bendz. G. and Lindquist, I., eds., Plenum P, New York, 1978, pp. 207–230.
E. M. Carlisle, inSilicon Biochemistry, Evered, D., ed., Ciba Found. Symp. 121, Wiley, Chichester, 1986, pp. 123–136.
E. M. Carlisle,Nutr. Rev. 40, 193–198 (1982).
J. Loeper, J. Goy-Loeper, L. Rozensztajn, and M. Fragny,Atherosclerosis 33, 397–408 (1979).
J. Loeper, J. Everit, J. Goy-Rozensztajn, and M. Fragny,Pathol. Biol. 32, 693–697 (1984).
J. Loeper, M. Fragny, R. Troniou, and O. Bedu,Life Sci. 42, 2105–2112 (1988).
J. D. Birchall and C. R. Chappell,Clin. Chem. 34, 265–267 (1988).
J. D. Birchall and A. W. Espie, inSilicon Biochemistry, Evered, ed., Ciba Found. Symp., 121, Wiley, Chichester, 1986, pp. 140–153.
G. M. Berlyne, A. J. Adler, N. Ferran, S. Bennett, and J. Holt,Nephron 43, 5–9 (1986).
G. M. Berlyne, E. Dudek, A. J. Adler, J. E. Rubin, and M. Seidman,Capri Conf., 1983,Kidney Int. 17, pp. 175–177.
J. W. Dobbie and J. B. Smith, inSilicon Biochemistry, Ciba Found. Symp., 121, Wiley, Chichester, 1986, pp. 194–209.
H. P. Misra and I. Fridovich,J. Biol. Chem. 247, 3170–3175 (1972).
R. F. Beers and I. Sizer,J. Biol. Chem. 195, 133–140 (1952).
D. E. Paglia and W. N. Valentine,J. Lab. Clin. Med. 70, 158–169 (1967).
O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall,J. Biol. Chem. 193, 265–275 (1951).
C. S. Wang and R. L. Smith,Anal. Biochem. 63, 414–417 (1975).
A. P. Autor, inThe Biology and Chemistry of Active Oxygen, Bannister, G. V. and Bannister, W. H., eds., Elsevier, New York, 1984, pp. 139–145.
B. M. Babior,Can. J. Physiol. Pharmacol. 60, 1353–1358 (1982).
X. Shi and N. S. Dafal,J. Toxicol. Environ. Hlth 25, 237–295.
R. Shainkin-Kestenbaum, A. J. Adler, and G. M. Berlyne,Trace Elem. Electrol. Health Dis. 4, 97–99 (1990).
S. Korke, Y. Kumo, and H. Morita,Jpn. J. Hyg. 37, 10–15.
R. Shainkin-Kestenbaum, A. Adler, A. Caruso, and G. M. Berlyne,Clin. Sci. 77, 463–466 (1989).
G. M. Berlyne, R. Shainkin-Kestenbaum, R. Yagil, Z. Alfassi, A. Kushelevsky, and Z. Etzion,Biol. Trace Elem. Res. 10, 1959–1962 (1986).
G. A. Sutherland, J. Glase, and P. Gabriel,Nephron 18, 182–184 (1977).
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Najda, J., Goss, M., Gmínski, J. et al. The antioxidant enzymes activity in the conditions of systemic hypersilicemia. Biol Trace Elem Res 42, 63–70 (1994). https://doi.org/10.1007/BF02990489
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DOI: https://doi.org/10.1007/BF02990489