Abstract
The effect of dietary selenium and vitamin E on plasma total (TC) and high density lipoprotein cholesterol (HDLC) was evaluated in 54 Sprague Dawley rats fed cholesterol/cholic acid enriched diets. Diets 1, 2, and 3 had no added selenium (low Se) and 0 (low), 60 (adequate), and 600 (high) mg/kg dL alpha tocopheryl acetate added respectively. Sodium selenite at 0.2 mg/kg (adequate Se) was added to diets 4, 5, and 6 and at 4.0 mg/kg (toxic Se) to diet 7, 8, and 9 with the same pattern of vitamin E added to the diet as described above. TC and HDLC were measured using the Kodak Ectachem system. Rats in the low and adequate Se groups fed high vitamin E had lower TC values than rats fed lower vitamin E levels but differences were not significant. In the toxic Se groups, rats fed high vitamin E had significantly (p<0.05) higher plasma TC values than did lower Vitamin E groups. Rats on the high vitamin E diets with low or adequate Se had significantly (p<0.05) higher mean plasma HDLC values when compared to rats fed low or adequate vitamin E diets. HDLC values for animals on Se toxic diets were significantly (p<0.05) lower in rats fed a low vitamin E diet. In rats fed Se deficient and adequate diets, a high vitamin E intake resulted in a decrease in TC and an increase in HDLC. In Se toxic rats, TC was elevated by a high dietary intake of vitamin E as was HDLC with both values being significantly higher than values found in the vitamin E deficient rats. Vitamin E deficiency resulted in a plasma lipid pattern that has been associated with greater cardiovascular disease risk.
Similar content being viewed by others
References
H. A. Tyrolu, inHypercholesterolemia and Atherosclerosis, D. Steinber and J. M. Gleisky, eds., Churchill Livingstone, New York, pp. 99–116 (1987).
Anonymous,JAMA 253, 2060–2066 (1985).
National Cholesterol Education Program Expert Panel,Arch. Intern. Med. 148, 36–39 (1988).
A. C. Tsai, J. J. Kelley, B. Peng, and N. CookAm. J. Clin. Nutr. 31, 831–837 (1978).
P. M. Farrell and J. G. Bieri,Am. J. Clin. Nutr. 28, 1381–1386 (1975).
M. J. Stampfer, W. Willett, W. R. Castelli, J. O. Taylor, J. Fine, and C. H. Hennekens,Am. J. Clin. Pathol. 79, 714–716 (1983).
W. J. Hermann, K. Ward, and J. Faucett,Am. J. Clin. Pathol. 72, 848–852 (1979).
R. V. Williams, J. M. Motteram, C. H. Sharp, and P. J. Gallagher,Atherosclerosis 94, 153–159 (1992).
J. E. Spallholz, G. F. Collins, and K. Schwartz,Bioinorg. Chem. 9, 453–459 (1978).
R. Martinek,Clin. Chem. 10, 1078–1085 (1964).
P. E. Paglia and W. N. Valentine,J. Lab. Clin. Med. 70, 158–169 (1967).
O. H. Lowery,J. Biol. Chem. 193, 265–275 (1951).
S. Vadhanavikit and H. E. Ganther,J. Nutr. 118, 718–722 (1988).
P. M. Kris-Etherton and A. D. Cooper,J. Lipid Res. 21, 435–442 (1980).
R. W. Mahley and K. S. Holcombe,J. Lipid Res. 18, 314–324 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Liu, W., Boylan, L.M. Alterations in plasma total and high density lipoprotein cholesterol levels in hyperlipidemic rats fed diets with varied content of selenium and vitamin E. Biol Trace Elem Res 42, 9–16 (1994). https://doi.org/10.1007/BF02990484
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02990484