Effect of boron on vitamin D deficient rats


The effects of different levels of dietary boron were determined in vitamin D deficient rats. Vitamin D deficient diets containing either 0.158 ppm or 2.72 ppm of boron were fed to rats for 11 w, and calcium, magnesium, and phosphorus apparent absorption and balance were measured in the twelfth week. Higher apparent absorption and balance values for calcium and phosphorus were observed in the rats with higher dietary boron, but very few differences were seen in body wt, organ wt, and bone parameters. Balance measurements represented the present status of the rats after 12 w on the diets, but other measurements represented an accumulation over the lifetime of the rat, including a suckling period with ample vitamin D and boron. The data demonstrated that when rats are vitamin D deficient, as indicated by hypocalcemia, the level of boron in the diet affects mineral balance.

This is a preview of subscription content, log in to check access.


  1. 1.

    C. D. Hunt and F. H. Nielsen, inTrace Element Metabolism in Man and Animals, 4th Intl. J. M. Howell, J. M. Gawthorne, and C. L. White, ed. Austral. Acad. Sci. Canberra, Australia, 597 (1981).

    Google Scholar 

  2. 2.

    F. H. Nielson,Annual Review of Nutrition, vol. 4, W. J. Darby, ed. Annual Reviews Inc., Palo Alto, CA, 21 (1984).

    Google Scholar 

  3. 3.

    C. D. Hunt,FASEB J. 3, A760 (1989).

    Google Scholar 

  4. 4.

    B. Brossart and F. H. Nielson,ND Acad. Sci. 40, 128 (1986).

    Google Scholar 

  5. 5.

    F. H. Nielsen, T. R. Shuler, T. J. Zimmerman, and E. O. Uthus,Biol. Trace Elem. Res. 17, 91 (1988).

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    F. H. Nielsen, D. R. Myron, S. H. Givand, and D. A. Ollerich,J. Nutr. 105, 1607 (1975).

    PubMed  CAS  Google Scholar 

  7. 7.

    P. S. Chen, Jr., T. Y. Toribara, and H. Warner,Anal. Chem. 28, 1756 (1956).

    Article  CAS  Google Scholar 

  8. 8.

    J. W. Pike,Nutr. Rev. 43, 161 (1985).

    PubMed  CAS  Article  Google Scholar 

  9. 9.

    Personal communication with R. Brommage, Nestle Co., Switzerland.

  10. 10.

    J. L. Underwood, M. E. Phelps, and H. F. DeLuca,Proc. Natl. Acad. Sci. USA 81, 2352 (1984).

    PubMed  Article  CAS  Google Scholar 

  11. 11.

    J. G. Penland,FASEB J. 4, A1045 (1990).

    Google Scholar 

  12. 12.

    J. G. Penland,FASEB J. 3, A1242 (1989).

    Google Scholar 

  13. 13.

    C. D. Hunt and F. H. Nielsen, In:6th Intl Symposium on Trace Elements in Man and Animals, L. S. Hurley, C. L. Keen, B. Lonnerdal, and R. B. Rucker, ed. Plenum Publishing, NY, NY, 275 (1988).

    Google Scholar 

  14. 14.

    B. P. Halloran,Nutr. Rep. Intl. 31, 1149 (1985).

    CAS  Google Scholar 

  15. 15.

    M. Keenan, M. Hegsted, and R. Mohan,FASEB J. 2, A1098 (1988).

    Google Scholar 

  16. 16.

    J. L. Underwood and H. F. DeLuca,Am. J. Physiol. 246, E493 (1984).

    PubMed  CAS  Google Scholar 

  17. 17.

    F. H. Nielsen,FASEB J. 3, A760 (1989).

    Google Scholar 

  18. 18.

    F. H. Nielsen, C. D. Hunt, L. M. Mullen, and J. R. Hunt,FASEB J. 1, 394 (1987).

    PubMed  CAS  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Maren Hegsted.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hegsted, M., Keenan, M.J., Siver, F. et al. Effect of boron on vitamin D deficient rats. Biol Trace Elem Res 28, 243–255 (1991). https://doi.org/10.1007/BF02990471

Download citation

Index Entries

  • Boron
  • vitamin D
  • calcium
  • magnesium
  • phosphorus
  • apparent absorption and balance
  • hypocalcemia