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The distribution and half-life for retention of vanadium in the organs of normal and diabetic rats orally fed vanadium(IV) and vanadium(V)

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Abstract

The concentration of vanadium in organs of diabetic rats that had been fed vanadium, either as V(IV) or V(V), in their drinking water has been determined. The kidney was found to have the highest concentration, about 185 nmol/g wet tissue. This averages about three times higher than for the liver or spleen, for which concentrations were comparable. The lung, blood plasma, and blood cells tended to have the lowest accumulations of vanadium. A time-course study indicated that the half-life for elimination of vanadium from the bodies of vanadium-fed rats is about 12 d.

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Authors and Affiliations

  1. Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, V6T 1W5, Vancouver, BC, Canada

    Sasanka Ramandham, Clayton Heyliger & John H. McNeill

  2. Department of Chemistry, Simon Fraser University, V5A 1S6, Burnaby, BC, Canada

    Michael J. Gresser & Alan S. Tracey

  3. Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada Inc., CP 1005, H9R 4P8, Pointe-Claire-Dorval, Quebec, Canada

    Michael J. Gresser

  4. The Center for Biotechnology, Baylor College of Medicine, 4000 Research Forest Drive, 877381, The Woodlands, Texas

    Sasanka Ramandham

  5. Department of Physiology, Mehurry Medical School, Nashville, Tennessee

    Clayton Heyliger

Authors
  1. Sasanka Ramandham
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  2. Clayton Heyliger
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  3. Michael J. Gresser
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  4. Alan S. Tracey
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  5. John H. McNeill
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Ramandham, S., Heyliger, C., Gresser, M.J. et al. The distribution and half-life for retention of vanadium in the organs of normal and diabetic rats orally fed vanadium(IV) and vanadium(V). Biol Trace Elem Res 30, 119–124 (1991). https://doi.org/10.1007/BF02990348

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  • DOI: https://doi.org/10.1007/BF02990348

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