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Cytotoxicity of zinc chloride in mice in vivo

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Abstract

Intraperitoneal administration of zinc chloride (ZnCl2) to Swiss albino mice in vivo induced a significant (p≤0.05) increase in the frequencies of chromosomal aberrations of the bone-marrow cells at all concentrations used following acute (7.5, 10, 15 mg/kg body weight) and chronic (2.0, 3.0 mg/kg body wt) treatment. The degree of clastogenicity was directly proportional to the concentrations (p≤0.05, trend test) and indirectly to the period of treatment (p≤0.05, ANOVA test). It induced a dose-dependent, statistically significant increase (Mann-Whitney U statistics, student'st-test) in sperm-head abnormalities. The data designate ZnCl2 as a potent clastogen and as a toxic chemical at the concentrations used.

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Author notes

  1. Tarun Gupta

    Present address: Institute of Post Graduate Medical Education and Research, University of Calcutta, 700 019, Calcutta, India

Authors and Affiliations

  1. Centre for Advanced Study in Cell and Chromosome Research, Department of Botany, University of Calcutta, 35 Ballygunge Circular Road, 700 019, Calcutta, India

    Tarun Gupta, Geeta Talukder & Archana Sharma

Authors
  1. Tarun Gupta
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  2. Geeta Talukder
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  3. Archana Sharma
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Gupta, T., Talukder, G. & Sharma, A. Cytotoxicity of zinc chloride in mice in vivo. Biol Trace Elem Res 30, 95–101 (1991). https://doi.org/10.1007/BF02990346

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  • DOI: https://doi.org/10.1007/BF02990346

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