Abstract
The rate and site of fluoride (F) absorption were compared in fasted 350 g male rats given 50 μg F (as NaF) in either water or a 7.5% pectin solution. Absorption was measured at intervals up to 2 h following gastric intubation. Gastric emptying was measured by inclusion of14C-PEG in the F solution. The extent of gastric F absorption was derived from rates of gastric emptying (14C-PEG loss) and F loss. Pectin markedly slowed gastric emptying, but by 2 h, more than 90% of the solution had passed into the small intestine in both groups, and F absorption exceeded 90% in both groups. The rate of F absorption was initially much slower in the pectin group than in the group given F in water, and plasma F concentration increased more slowly and reached a lower maximum value. Absorption from the stomach was greater in the pectin group, but still accounted for only approx 25% of total gastrointestinal absorption. The reduced rate of F absorption and slower rise in plasma F concentration accompanying delayed gastric emptying indicate that passage of F into the small intestine is the major factor in rapid F absorption.
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Messer, H.H., Ophaug, R. Effect of delayed gastric emptying on fluoride absorption in the rat. Biol Trace Elem Res 31, 305–315 (1991). https://doi.org/10.1007/BF02990199
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DOI: https://doi.org/10.1007/BF02990199