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The influence of volatile anesthetics on alveolar epithelial permeability measured by noninvasive radionuclide lung scan

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Abstract

Many volatile anesthetics have long been thought to affect pulmonary functions including lung ventilation (LV) and alveolar epithelial permeability (AEP). The purpose of this study is to examine the influence of volatile anesthetics on LV and AEP by noninvasive radionuclide lung imaging of technetium-99m labeled diethylene triamine pentaacetic acid radioaerosol inhalation lung scan (DTPA lung scan).

Twenty patients undergoing surgery and receiving volatile anesthesia with 1% halothane were enrolled as the study group 1. The other 20 patients undergoing surgery and receiving volatile anesthesia with 1.5% isoflurane were enrolled as the study group 2. At the same time, 20 patients undergoing surgery with intravenous anesthesia drugs were included as a control group. Before surgery, 1 hour after surgery, and 1 week after surgery, we investigated the 3 groups of patients with DTPA lung scan to evaluate LV and AEP by99mTc DTPA clearance halftime (T1/2).

No significant change or abnormality of LV before surgery, 1 hour after surgery, or 1 week after surgery was found among the 3 groups of patients. In the control group, the99mTc DTPA clearance T1/2 was 63.5±16.4, 63.1±18.4, and 62.8±17.0 minutes, before surgery, 1 hour after surgery, and 1 week after surgery, respectively. In group 1, it was 65.9±9.3, 62.5±9.1, and 65.8±10.3 minutes, respectively. No significant change in AEP before surgery, 1 hour after surgery, or 1 week after surgery was found. However, in group 2, the99mTc DTPA clearance T1/2 was 65.5±13.2, 44.9 44.9±10.5, and 66.1±14.0 minutes, respectively. A significant transient change in AEP was found 1 hour after surgery, but it recovered 1 week after surgery.

We conclude that volatile anesthesia is safe for LV and AEP, and only isoflurane can induce transient change of AEP.

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Authors and Affiliations

  1. Department of Anesthesia, Pain Clinic & Critical Care Medicine, China Medical College Hospital, No. 2, Yuh-Der Road, 404, Taichung, Taiwan

    Chih-Jen Hung & Rick Sai-Chuen Wu

  2. Department of Family Medicine, China Medical College Hospital, No. 2, Yuh-Der Road, 404, Taichung, Taiwan

    Cheng-Chieh Lin

  3. Department of Medical Research, China Medical College Hospital, No. 2, Yuh-Der Road, 404, Taichung, Taiwan

    Albert Kao

  4. Department of Nuclear Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan

    Feng-Yuan Liu

  5. Graduate Institute of Bioinformatics, Taichung Healthcare and Management University, Taichung, Taiwan

    Jeffrey J. P. Tsai

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  1. Chih-Jen Hung
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  2. Feng-Yuan Liu
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  3. Rick Sai-Chuen Wu
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  4. Jeffrey J. P. Tsai
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  5. Cheng-Chieh Lin
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  6. Albert Kao
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Correspondence to Albert Kao.

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Hung, CJ., Liu, FY., Wu, R.SC. et al. The influence of volatile anesthetics on alveolar epithelial permeability measured by noninvasive radionuclide lung scan. Ann Nucl Med 17, 213–218 (2003). https://doi.org/10.1007/BF02990024

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  • DOI: https://doi.org/10.1007/BF02990024

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