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Processing of peptide precursors

Identification of a new family of mammalian proteases

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Conclusions

Much further work will be necessary to define more fully this novel and growing mammalian family of kex2-like proteases, and future years should bring a more detailed understanding of their mechanisms and roles in precursor processing. This knowledge may also provide new insights into the mechanisms by which precursors are sorted into the appropriate intracellular organelles, correctly modified posttranslationally, processed proteolytically into their desired products, and ultimately delivered in a regulated fashion to their sites of release or action.

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Author notes

  1. Steven P. Smeekens

    Present address: Chiron Corp., 4560 Horton St., 94608, Emeryville, CA

Authors and Affiliations

  1. Howard Hughes Medical Institute, The university of Chicago, Chicago, IL

    Steven P. Smeekens & Donald F. Steiner

  2. Department of Biochemistry and Molecular Biology, The university of Chicago, Chicago, IL

    Steven P. Smeekens & Donald F. Steiner

Authors
  1. Steven P. Smeekens
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  2. Donald F. Steiner
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Smeekens, S.P., Steiner, D.F. Processing of peptide precursors. Cell Biophysics 19, 45–55 (1991). https://doi.org/10.1007/BF02989878

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