Control of cisplatin induced emesis — A multidisciplinary intervention strategy

  • Carl Johan Fürst
  • Sussanne Johansson
  • Mats Fredrikson
  • Timo Hursti
  • Gunnar Steineck
  • Curt Peterson


A pharmacological, behavioural and nursing intervention strategy was evaluated for prevention of cisplatin (50 mg m-2) induced emesis in ovarian cancer patients. 46 patients received metoclopramide 2.5 mg kg-1 i.V., b.i.d., dexamethasone 20 mg i.V., lorazepam and biperiden as well as training in relaxation, nutritional advice and continuity in nursing care. Controls (n = 34) received standard treatment (metoclopramide 10-20 mg i.v. or dixyracin 20 mg i.V.). The intensity and duration of nausea and vomiting were significantly lower and measures of quality of life higher for patients on the experimental ward during the three cycles that were studied. No significant changes in emesis were observed between the cycles. There was no correlation between emesis and any of the parameters of quality of life measured. The reliability and validity of nausea ratings are discussed and we suggest that an underreporting of nausea and vomiting might be common.

Key Words

Nausea Vomiting Cisplatin Ovarian cancer Metoclopramide Relaxation Nursing Diet Multidisciplinary 


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Copyright information

© Humana Press Inc. 1992

Authors and Affiliations

  • Carl Johan Fürst
    • 1
  • Sussanne Johansson
    • 1
  • Mats Fredrikson
    • 3
  • Timo Hursti
    • 3
  • Gunnar Steineck
    • 1
  • Curt Peterson
    • 2
  1. 1.Dept. of General OncologyRadiumhemmet, Karolinska HospitalStockholmSweden
  2. 2.Dept. of Clinical PharmacologyKarolinska Institute and HospitalStockholmSweden
  3. 3.Dept. of Medical PsychologyKarolinska Institute and HospitalStockholmSweden

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