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Bone marrow cells in the DNA-synthesis-phase in the myelodysplastic syndrome and lymphome

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Abstract

The bromodeoxyuridine (BRDU) labelling of bone marrow cells was studied in 46 subjects. The labelling in 14 patients, mostly untreated, with the myelodysplastic syndrome (MDS) and four lymphoma patients was significantly (p = 0.043) higher (11.38 ± SE 2.3 % S-phase cells) than that of marrow cells (7.18 ± SE 1.04%) from 14 apparently healthy normal controls and from nine patients with non hematologic disease. Six iron deficiency had numerically but not significantly increased values. Bone marrow samples from MDS-patients showing the highest numbers of cells in the DNA-synthesis phase had the lowest numbers of colonies and clusters in the CFU-C assay(p < 0.03). The data suggest that the DNA-synthesis period is longer in MDS than in controls.

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Authors and Affiliations

  1. Hematology laboratories, Karolinska Hospital and Institute, Stockholm, Sweden

    Anne-Marie Wenthzel, Karin Lindahl, Suzanne Widell & Peter Reizenstein

  2. Immunopathology laboratories, Karolinska Hospital and Institute, Stockholm, Sweden

    Anja Porwit

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  1. Anne-Marie Wenthzel
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  2. Anja Porwit
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  3. Karin Lindahl
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  4. Suzanne Widell
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  5. Peter Reizenstein
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Wenthzel, AM., Porwit, A., Lindahl, K. et al. Bone marrow cells in the DNA-synthesis-phase in the myelodysplastic syndrome and lymphome. Med Oncol. & Tumor Pharmacother. 9, 51–55 (1992). https://doi.org/10.1007/BF02989654

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  • DOI: https://doi.org/10.1007/BF02989654

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