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Leukemic progression as process of adaptation (theoretical model)

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Abstract

On the basis of an assumption that leukemic progression is a process of adaptation of normal hemopoiesis to the effect of the leukemic clone, a theoretical model of leukemia development is built. General conclusions are as follows: the possibility of reaching remission depends upon suppression of normal hemopoiesis by cytostatics in a system of two cell populations: the duration of remission depends uponsuppression of the leukemic clone; the quantity of blast cells of marrow in remission can exceed 5 per cent.

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Authors and Affiliations

  1. Department of Haematology and Bone Marrow Transplantation, All-Union Scientific Centre for Haematology of the USSR Ministry of Health, Novozykovsky Proezd, 4., 125167, Moscow, Russia

    Igor V. Alekseyev

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  1. Igor V. Alekseyev
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Alekseyev, I.V. Leukemic progression as process of adaptation (theoretical model). Med Oncol. & Tumor Pharmacother. 9, 47–50 (1992). https://doi.org/10.1007/BF02989653

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