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Genetic aspects of multidrug resistance

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Abstract

Gene amplification is responsible both for dihydrofolate reductase induced methotrexate resistance, and for the P-glycoprotein encoding multigene family induced multidrug resistance. The 6 pairs of hydrophobic regions of the P-glycoprotein fold up in a snake-like structure through the lipidic layers of the cell membrane. Other detoxification mechanisms include the glutathione S-transferase ‘pi’, but without gene amplification.

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Authors and Affiliations

  1. Laboratoire de recherche sur le cancer et les maladies du sang, Z.I. Grasbusch, L-3370, Leudelange, Grand-Duchy ofLuxembourg

    Marc Pauly

  2. Département d’Hemato-Oncologie, Centre hospitalier de Luxembourg, Rue Barblé 4, L-1210, Luxembourg

    Fernand Ries & Mario Dicato

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  1. Marc Pauly
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  2. Fernand Ries
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  3. Mario Dicato
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Pauly, M., Ries, F. & Dicato, M. Genetic aspects of multidrug resistance. Med Oncol. & Tumor Pharmacother. 9, 21–24 (1992). https://doi.org/10.1007/BF02989649

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  • DOI: https://doi.org/10.1007/BF02989649

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