Abstract
In a preceding trial, the growth hormone concentrations in the serum of zinc-deficient rats were greatly reduced compared to thead libitum- fed control animals. The same reduction, however, was also noted in the case of the pair-fed control animals with strongly diminished feed intake. Therefore, it was not possible to distinguish between the effects of zinc deficiencyper se and the effects resulting from restricted feed intake.
A new study with 136 young male Sprague-Dawley rats showed again that zinc deficiency as well as strongly restricted feed intake reduced the growth hormone content in the serum. But in a marginal zinc deficiency status, when feed intake was only slightly or not reduced, there were lowered serum growth hormone levels in comparison to pair-fed control rats. A 1-wk zinc repletion did not increase the serum growth hormone content of the rats to a normal level, although the serum zinc concentration was normalized.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
H.-P. Roth and M. Kirchgessner,Z. Tierphysiol., Tierernährg. u. Futtermittelkde. 47, 197 (1982).
A. W. Root, G. Duckett, M. Sweetland, and E. O. Reiter,J. Nutr,109, 958 (1979).
H.-P. Roth, U. Schneider, and M. Kirchgessner,Arch. Tierernährg. 25, 545 (1975).
A. Linder,Statistische Methoden für Naturwissenschaftler, Mediziner und Ingenieure. 3, Auflage, Birkhäuser Verlag, Basel and Stuttgart, 1960.
M. J. Millar, N. R. Vincent, and C A. Mawson,J. Histochem. Cytochem. 9, 111 (1961).
J. M. Orten, inZinc Metabolism, A. S. Prasad, ed., Charles C Thomas, Springfield, Illinois, 1966, pp. 38–47.
J. Meites and N. J. Fiel,Endocrinology 77, 455 (1965).
B. L. Pimstone, G. Barbezat, J. D. L. Hamsen, and P. Murray,Amer, J. Clin, Nutr. 21, 482 (1969).
W. H. Daughaday and D. M. Kipnis,Rec. Prog. Horm. Res,22, 49 (1966).
N. N.,Nutr. Rev,35, 150 (1977).
G. A. Campbell, M, Kurcz, S. Marshall, and J. Meites,Endocrinology 100, 580 (1977).
L. S. Phillips and H, S. Young,Endocrinology 99, 304 (1976).
R. Hammermann, M. Kirchgessner, and H.-P. Roth, Ms in preparation (1984).
S. Z. Ghavami-Maibodi, P. J. Collipp, M. Castro-Magana, C. Stewart, and S. Y. Chen,Ann. Nutr. Metab,27, 214 (1983).
Z. T. Cossack,Expenentia 40, 498 (1984).
P. J, Collipp, M. Castro-Magana, M. Petrovic, J. Thomas, T. Cheruvanky, S. Y. Chen, and H. Sussman,Ann. Nutr. Metab. 26, 287 (1982),
T. Cheruvanky, M. Castro-Magana, S. Y. Chen, P. J. Collipp, and Z. G. Maibodi,Amer. J. Clin. Nutr. 35, 668 (1982).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kirchgessner, M., Roth, HP. Influence of zinc depletion and zinc status on serum growth hormone levels in rats. Biol Trace Elem Res 7, 263–268 (1985). https://doi.org/10.1007/BF02989251
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02989251