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Metabolic effects of high doses of manganese in rats

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Abstract

The effects of acute manganese (Mn) toxicity on tissue manganese concentrations and on plasma glucose levels were investigated in adult male Sprague-Dawley rats. Manganese injection in all tissues analyzed was reflected by a significant increase in Mn concentration that was transitory. Changes in the molecular localization of Mn in liver following injection include both increases in protein-bound Mn and low molecular weight Mn complexes. A rapid, dose-responsive rise in blood glucose followed Mn injection, whereas circulating insulin levels decreased after injection. These data show that acute changes in tissue Mn levels can have a pronounced effect on carbohydrate metabolism.

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References

  1. A. R. Kemmerer, C. A. Elvehjem, and E. B. Hart,J. Biol. Chem. 92, 623 (1931).

    CAS  Google Scholar 

  2. E. R. Orent and E. V. McCollum,J. Biol. Chem. 92, 651 (1931).

    CAS  Google Scholar 

  3. C. L. Keen, B. Lönnerdal, and L. S. Hurley, Biochemistry of the Essential Ultra-Trace Elements, E. Frieden, ed., Plenum, New York, in press.

  4. M. Hassanein, H. A. Ghaleb, E. A. Haroun, M. R. Hegazy, and M. A. H. Khayyal,Brit. Industr. Med. 23, 67 (1966).

    CAS  Google Scholar 

  5. R. Husain, M. Mushtag, and P. K. Seth,Bull. Environ. Contam. Toxicol. 25, 646 (1980).

    Article  PubMed  CAS  Google Scholar 

  6. V. L. Schramm,Trends Biochem. Sci. 7, 369 (1982).

    Article  CAS  Google Scholar 

  7. M. S. Clegg, C. L. Keen, B. Lönnerdal, and L. S. Hurley,Biol. Trace Elem. Res. 3, 107 (1981).

    Article  CAS  Google Scholar 

  8. B. Lönnerdal and B. Hoffman,Biol. Trace Elem. Res. 3, 301 (1981).

    Google Scholar 

  9. J. S. Stern, C. R. Johnson, B. Batchelsi, L. M. Zucker, and J. Hirsch,Am. J. Physiol. 228, 543 (1975).

    PubMed  CAS  Google Scholar 

  10. H. Suzuki and O. Wada,Environ. Res. 26, 521 (1981).

    Article  PubMed  CAS  Google Scholar 

  11. A. Foradori and M. Dinamarca,Rev. Med. Chile 100, 148 (1972).

    PubMed  CAS  Google Scholar 

  12. D. Mangnall, A. E. B. Giddings, and R. G. Clark,Int. J. Biochem. 7, 293 (1976).

    Article  CAS  Google Scholar 

  13. R. Rognstad,J. Biol. Chem. 256, 1608 (1981).

    PubMed  CAS  Google Scholar 

  14. P. Rorsman, P. O. Berggren, and B. Hellman,Biochem. J. 202, 435 (1982).

    PubMed  CAS  Google Scholar 

  15. D. L. Baly, D. L. Curry, C. L. Keen, and L. S. Hurley,J. Nutr., in press.

  16. P. A. Taylor and J. D. E. Price,Can. Med. Assoc. J. 126, 503 (1982).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Nutrition, University of California, 95616, Davis, California

    Carl L. Keen, Deborah L. Baly & Bo Lönnerdal

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  1. Carl L. Keen
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  2. Deborah L. Baly
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  3. Bo Lönnerdal
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Keen, C.L., Baly, D.L. & Lönnerdal, B. Metabolic effects of high doses of manganese in rats. Biol Trace Elem Res 6, 309–315 (1984). https://doi.org/10.1007/BF02989238

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  • DOI: https://doi.org/10.1007/BF02989238

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