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A case of cavernous hemangioma of the small intestine diagnosed by scintigraphy with Tc-99m-labeled red blood cells

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Hemangioma of the small intestine is rare, and the preoperative diagnosis of it is difficult. We report a patient with gastrointestinal bleeding for whom Tc-99m-labeled red blood cell scintigraphy was useful in diagnosing cavernous hemangioma of the small intestine. A 25-year-old man was referred to our hospital for recurrent iron deficiency anemia. Because of the patient’s severe anemia, imaging was performed to locate the bleeding lesion in the gastrointestinal tract. Scintigraphy with Tc-99m-labeled red blood cells revealed pooling indicating a tumor and extravasation of blood from the tumor. Scintigraphy with Tc-99m pertechnetate revealed no abnormal accumulation. Partial resection of the small intestine was done, and cavernous hemangioma of the small intestine was diagnosed by using the specimen of resected tissue.

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  1. Taylor TV, Torrance HB. Hemangiomas of gastrointestinal tract.Br J Surg 61: 236–238, 1974.

    Article  PubMed  CAS  Google Scholar 

  2. Byle L, Lack EE. Solitary cavernous hemangioma of small intestine. Case report and literature review.Arch Pathol Lab Med 117: 939–941, 1993.

    Google Scholar 

  3. Winzelberg GG, Mckusick KA, Strauss HW, Waltman AC, Greenfield AJ. Evaluation of gastrointestinal bleeding by red blood cells labeledin-vivo with technetium-99m.J Nucl Med 20: 1080–1086, 1979.

    PubMed  CAS  Google Scholar 

  4. Seto H, Kageyama M, Wu Y-W, Shimizu M, Nagayoshi T, Watanabe N, et al. Sequential subtraction scintigraphy with99mTc-RBC for early detection of gastrointestinal bleeding.Ann Nucl Med 9: 203–208, 1995.

    PubMed  CAS  Google Scholar 

  5. Yoshikai T, Yokomizo Y, Iwashita I, Okada Y, Koga H, Kudo S. Inferior mesenteric varix demonstrated by99mTc-red blood cell gastrointestinal bleeding study.Ann Nucl Med 11: 163–166, 1997.

    Article  PubMed  CAS  Google Scholar 

  6. Sos TA, Lee JG, Wixson D, Sniderman KW. Intermittent bleeding from minute to minute in acute massive gastrointestinal hemorrhage—Arteriographic demonstration.Am J Roentgenol 131: 1015–1017, 1978.

    CAS  Google Scholar 

  7. Barkin JS, Schonfeld W, Thomsen S, Manten HD, Rogers AI. Enteroscopy and small bowel biopsy—An improved technique for the diagnosis of small bowel disease.Gastrointest Endosco 31: 215–217, 1985.

    Article  CAS  Google Scholar 

  8. Akamatsu T, Matsuda Y, Tsugane E, Matsuzawa K, Hasebe O, Furuta S, et al. A case of multiple cavernous hemangioma of the small intestine and clinical review of Japanese literature.J Gastroenterol 25: 494–498, 1990.

    CAS  Google Scholar 

  9. Thorne DA, Datz FL, Remley K, Christian PE. Bleeding rates necessary for detecting acute gastrointestinal bleeding with Tc-99m labeled red blood cells in an experimental model.J Nucl Med 28: 514–520, 1987.

    PubMed  CAS  Google Scholar 

  10. Nusbaum M, Baum S. Radiographic demonstration for unknown sites of gastrointestinal bleeding.Surg Forum 14: 374–375, 1963.

    PubMed  CAS  Google Scholar 

  11. Briley CA, Jackson DC, Johnsrude IS, Mills SR. Acute gastrointestinal hemorrhage of small bowel origin.Radiology 136: 317–319, 1980.

    PubMed  Google Scholar 

  12. Wilson JM, Melvin DB, Gray G, Thorbjarmarson B. Benign small bowel tumor.Ann Surg 181: 247–250, 1975.

    PubMed  CAS  Google Scholar 

  13. Yanaguchi M, Takeuchi S, Awazu S. Meckel’s diverticulum —Investigation of 600 patients in Japanese literature.Am J Surg 136: 247–249, 1978.

    Article  Google Scholar 

  14. Kiesewetter WB. Meckel’s diverticulum in children.Arch Surg 75: 914–919, 1957.

    CAS  Google Scholar 

  15. Leijionmarck CE, Bonman-Sandelin K, Frisell J, Raf L. Meckel’s diverticulum in the adult.Br J Surg 73: 146–149, 1986.

    Article  Google Scholar 

  16. Sfakianakis GN, Conway JJ. Detection of ectopic mucosa in Meckel’s diverticulum and in other aberrations by scintigraphy: II. Indications and methods—A 10-year experience.J Nucl Med 22: 732–738, 1981.

    PubMed  CAS  Google Scholar 

  17. Imaeda T, Kanematsu M, Sone Y, Iinuma G, Hirose Y, Miya K, Shimokawa K. A case of intermittent bleeding Meckel’s diverticulum.Ann Nucl Med 4: 107–110, 1990.

    PubMed  CAS  Google Scholar 

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Correspondence to Susumu Shiomi.

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Iwata, Y., Shiomi, S., Oiso, R. et al. A case of cavernous hemangioma of the small intestine diagnosed by scintigraphy with Tc-99m-labeled red blood cells. Ann Nucl Med 14, 373–376 (2000).

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