Abstract
Ischemic “memory image” is a phenomenon of123I-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) in which an area at risk of acute myocardial infarction (AMI), could be detected as a defect in a couple of weeks even after successful reperfusion therapy.
The purpose of this study was to clarify the incidence of the ischemic “memory image” of123I-BMIPP in patients with AMI by comparing99mTc-PYP and201Tl dual-isotope SPECT.
Materials consisted of 14 patients with successfully reperfused AMI and 20 patients with old myocardial infarction (OMI). All AMI patients underwent PYP/Tl dual-isotope SPECT within 1 week after the onset of AMI, and BMIPP SPECT was performed within 1 week after the PYP/Tl dual-isotope SPECT. The extent and severity of the defect of BMIPP and Tl were visually scored into four grades: 0=no defect to 3=large or severe defect. These scores were compared.
PYP positive AMI lesions were concordant with BMIPP defects (13/14). In AMI, both the extent and severity scores of BMIPP were higher than201Tl (p<0.001). Differences (BMIPP-Tl) of extent and severity scores were greater in AMI than in OMI (p<0.001).
In conclusion, the ischemic “memory image” obtained by means of the BMIPP is a common phenomenon (13/14) in AMI, and helpful in evaluating the area at risk.
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Mochizuki, T., Murase, K., Higashino, H. et al. Ischemic “memory image” in acute myocardial infarctio of123I-BMIPP after reperfusion therapy: A comparison with99mTc-pyrophosphate and201Tl dual-isotope SPECT. Ann Nucl Med 16, 563–568 (2002). https://doi.org/10.1007/BF02988634
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DOI: https://doi.org/10.1007/BF02988634