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Brain perfusion SPECT study with99mTc-bicisate: Clinical pitfalls and improved diagnostic accuracy with a combination of linearization and scatter-attenuation correction

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Abstract

To evaluate the usefulness of a combination of linearization and seatter-attenuation correction on99mTc-bicisate (ECD)-single photon emission tomographic (SPECT) images, both cerebral blood flow (CBF)-positron emission tomographic (PET) images and ECD-SPECT images from fifteen patients with chronic cerebral infarction were acquired. We measured radioactivity counts in regions of interest (ROIs) on all sets of both images and obtained a 2D scattered graph between ECD-SPECT and CBF-PET data. To evaluate diagnostic accuracy, the sensitivity, specificity and accuracy of ECD-SPECT images were calculated by means of discriminant analysis. The same analysis was also performed on the ECD-SPECT images corrected by a combination of linearization and scatter-attenuation correction. An overall nonlinear relationship was observed between ECD-SPECT and CBF-PET. The sensitivity, specificity, and accuracy of ECD-SPECT images were 69.6%, 91.4% and 73.0%, and those of ECD images corrected by the combination of linearization and scatter-attenuation correction were 79.5%, 95.7% and 82.0% respectively. The clinically diagnostic accuracy of ECD-SPECT images corrected by the combined method apparently increased. So that the linearization with the scatter-attenuation method is useful for improving the diagnostic accuracy of ECD-SPECT images.

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Authors and Affiliations

  1. Department of Radiology, Fukui Medical University, 23 Shimoaizuki, Matsuoka-cho, Yoshida-gun, 910-1193, Fukui, Japan

    Hirotsugu Kado, Hirohiko Kimura, Tatsuro Tsuchida & Harumi Itoh

  2. Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan

    Hidehiro Iida, Toshihide Ogawa, Yuichiro Narita & Jun Hatazawa

  3. Biomedical Imaging Research Center, Fukui Medical University, Fukui, Japan

    Yoshiharu Yonekura

Authors
  1. Hirotsugu Kado
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  2. Hidehiro Iida
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  3. Hirohiko Kimura
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  4. Toshihide Ogawa
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  5. Yuichiro Narita
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  6. Jun Hatazawa
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  7. Tatsuro Tsuchida
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  8. Yoshiharu Yonekura
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  9. Harumi Itoh
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Correspondence to Hirotsugu Kado.

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Kado, H., Iida, H., Kimura, H. et al. Brain perfusion SPECT study with99mTc-bicisate: Clinical pitfalls and improved diagnostic accuracy with a combination of linearization and scatter-attenuation correction. Ann Nucl Med 15, 123–129 (2001). https://doi.org/10.1007/BF02988602

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  • DOI: https://doi.org/10.1007/BF02988602

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