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Conjugated dienoic derivatives of linoleic acid: A new class of anticarcinogens

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Abstract

Evidence establishing the anticarcinogenic activity of the conjugated dienoic derivatives of linoleic acid (CLA) is reviewed. Our findings demonstrate that CLA is a potent antioxidant and that the c-9,t-11 CLA isomer is selectively incorporated into cellular phospholipid, which may at least in part explain the anticarcinogenic activity of CLA. Dietary sources of CLA include grilled beef, cheese, and related foods. Another source of CLA is its endogenous generation via the carbon centered free radical oxidation of linoleic acid. We propose that the formation and action of CLA represents a previously unrecognizedin situ defense mechanism against membrane attack by oxygen radicals.

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  1. Food Research Institute, University of Wisconsin-Madison, 1925 Willow Drive, 53706, Madison, WI, USA

    Michael W. Pariza & Yeong L. Ha

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  1. Michael W. Pariza
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  2. Yeong L. Ha
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Pariza, M.W., Ha, Y.L. Conjugated dienoic derivatives of linoleic acid: A new class of anticarcinogens. Med. Oncol. & Tumor Pharmacother. 7, 169–171 (1990). https://doi.org/10.1007/BF02988544

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  • DOI: https://doi.org/10.1007/BF02988544

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