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Clinical approach to renal study incidental to99mTc-MDP bone scintigraphy

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Abstract

In order to investigate the feasibility of the assessment of renal function with99mTc-MDP, we compared renographical images, renogram patterns and the glomerular filtration rate (GFR) obtained by means of a modified Gates’ method and 200 MBq of99mTc-MDP with those obtained by means of99mTc-DTPA. Because 19 of 20 patients had malignant tumors in the genitourinary tract, there was no difference between the two tracers in identifying a parenchymal defect corresponding to renal cancer. Of eight patients with hydronephrosis, four had a defect or decreased uptake with a dilated pelvis, whereas the other four had marked radioisotope retention in the renal pelvis or the whole kidney on serial images. There was also no difference between the two tracers in identifying hydronephrosis. Of 38 paired renograms 35 showed the same renogram patterns with both tracers. Of three patients with different renogram patterns, two had hydronephrosis. In 20 patients including three patients with bone metastasis, total GFR and split GFR obtained with both tracers correlated with a correlation coefficient of r=0.920 (p<0.001) and r=0.944 (p<0.001), respectively. Excluding bone metastasis from the analysis, a linear-regression analysis showed excellent agreement between the two measurements with a correlation coefficient of r=0.960 (p<0.001) and r=0.963 (p<0.001), respectively. The linear regression equations were Y=1.009X −0.111 and Y=1.034X−0.714, respectively. In conclusion,99mTc-MDP can be used as a supplement to evaluate renal function incidental to the survey of bone metastases in patients with malignant tumor.

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Authors and Affiliations

  1. Department of Nuclear Medicine, School of Medicine, Kanazawa University, 5-11-80 Kodatsuno, 920-0942, Kanazawa, Japan

    Seigo Kinuya & Norihisa Tonami

  2. Department of Urology, Kaga Central Hospital, Kaga, Japan

    Kazunori Kobashi

  3. Department of Clinical Radiological Technology, School of Health Sciences, Faculty of Medicine, Kanazawa University, 5-11-80 Kodatsuno, 920-0942, Kanazawa, Japan

    Teruhiko Takayama, Masahisa Onoguchi, Yuji Mizukami, Kichiro Koshida & Shiro Tsuji

Authors
  1. Teruhiko Takayama
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  2. Seigo Kinuya
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  3. Kazunori Kobashi
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  4. Masahisa Onoguchi
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  5. Yuji Mizukami
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  6. Kichiro Koshida
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  7. Shiro Tsuji
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  8. Norihisa Tonami
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Correspondence to Teruhiko Takayama.

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Takayama, T., Kinuya, S., Kobashi, K. et al. Clinical approach to renal study incidental to99mTc-MDP bone scintigraphy. Ann Nucl Med 15, 237–245 (2001). https://doi.org/10.1007/BF02987838

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  • DOI: https://doi.org/10.1007/BF02987838

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