Preventing relapses of breast cancer with modified radical mastectomy

  • E. Forni
  • M. G. Valesi


Better prevention and early detection have improved the percentage of early cancers among all the treated breast tumors to about 40%. After the first demonstration in Milan in 1981 that even conservative surgery can effectively prevent tumor relapses, radical and modified radical mastectomy was compared in 136 and 127 women, respectively. The groups were well stratified as regards age, menopause, T- and N-status. No difference was found in 10-yr survival (58.8 and 59.8%, respectively) or local relapses (9.5 and 10%, respectively) or general relapses. The median disease-free survival was 10 yr in both groups. The results suggest that in Tl-T2a, N0-Nlb M0 unilateral breast cancer relapses are prevented as effectively with modified radical as with radical mastectomy.

Key words

Breast cancer Modified radical mastectomy Radical mastectomy 


  1. 1.
    Veronesi Uet al.: Conservative treatment of early breast cancer. Long-term results in 1232 cases treated with quadrantectomy, axillary dissection and radiotherapy.Ann Surg 211, 250 (1990).PubMedGoogle Scholar
  2. 2.
    Kinne D W: Primary therapy for limited breast cancer.Cancer 65, 2129 (1990).CrossRefPubMedGoogle Scholar
  3. 3.
    Veronesi U: Rationale and indications for limited surgery in breast cancer: Current data.Wld J Surg. 11, 493 (1987).CrossRefGoogle Scholar
  4. 4.
    Veronesi Uet al.: Quadrantectomy versus lumpectomy for small size breast cancer.Eur J Cancer 26, 671 (1990).PubMedCrossRefGoogle Scholar
  5. 5.
    Veronesi U, Saccozzi R, Del Vecchio Met al.: Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast.N Engl J Med 305, 6 (1981).PubMedGoogle Scholar
  6. 6.
    Fisher B, Margolese Ret al.: Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer.N Engl J Med 312, 665 (1985).PubMedGoogle Scholar
  7. 7.
    Fisher Bet al.: Eight-year’s results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer.N Engl J Med 13, 822 (1989).Google Scholar
  8. 8.
    Hayward J: The conservative treatment of early breast cancer.Cancer 33, 593 (1974).CrossRefPubMedGoogle Scholar
  9. 9.
    Sarrazin Det al.: Ten-year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer.Radiat Oncol 14, 177 (1989).CrossRefGoogle Scholar

Copyright information

© Humana Press Inc. 1991

Authors and Affiliations

  • E. Forni
    • 1
  • M. G. Valesi
    • 1
  1. 1.Department of SurgeryUniversity of PaviaPaviaItaly

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