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Medical Oncology and Tumor Pharmacotherapy

, Volume 8, Issue 3, pp 155–158 | Cite as

Prevention of chemotherapy-induced leukemia and of leukemia relapses

  • Emil J. Freireich
Article
  • 15 Downloads

Abstract

Fifty percent of patients with the myelodysplastic syndrome, frequently following treatment by radiation or chemotherapy, have prognostically unfavorable deletions of the long arms of chromosomes 5 and 7, or trisomy 8, as have the 25% of patients with acute myeloblastic leukemia where remissions last 6–12 months, and where relapse cannot be prevented. In contrast, patients with prognostically favorable cytogenetics (translocation 15; 17 or 8; 21 or inversion 16) maintenance chemotherapy may prevent relapses. Of chronic myelocytic leukemia patients, 85% can achieve hematological remission with interferon α, and 40% a partial cytogenetic remission, which probably delays relapse.

Key words

Leukemia Prevention Molecular genetics Residual disease Cytogenetics Treatment 

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References

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Copyright information

© Humana Press Inc. 1991

Authors and Affiliations

  • Emil J. Freireich
    • 1
  1. 1.Anderson Cancer CenterThe University of TexasHoustonUSA

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