Abstract
32 Dutch human milk samples were analyzed for PCBs with either HRGC-ECD or HRGC-LRMS in the NCI mode. Samples were collected from three different locations in The Netherlands: Amsterdam, Rotterdam and Groningen. Quantitatively, no differences could be observed between the three localities, while in addition the congener specific pattern showed a striking similarity for all individual samples. Only principal component analysis revealed slight individual differences. Based on similarities in the PCB profiles, linear relationships were calculated between 2,3′4,4′,5-PnCB (#118) or 2,2′4,4′5,5′HxCB (#153) and the most relevantnon andmonoortho PCBs exhibiting dioxinlike activity. These PCBs included 2,3,3′,4,4′-PnCB (#105), 3,3′,4,4′5-PnCB (#126) 2,3,3′,4,4′,5-HxCB (#156), 2,3,3′,4,4′,5′-HxCB (#157), 2,3′,4,4′,5,5′-HxCB (#167) and 3,3′,4,4′,5′5-HxCB (#169).
Good linear relationships were observed between individual PCBs. Based on the results of this study, PCB #118 can be used to predict concentrations of the PCBs #105 and #126. PCB #153 can be used as a predictor for the PCBs #156, #157, #167 and #169, but also for the total toxic equivalencies (TEQs) ofnon andmonoortho PCBs present in human milk. This method using certain PCBs as predictors for other toxicological relevant congeners, can be useful and cost effective, e.g. for epidemiological studies. However, before applied a number of conditions should be met. These are:
-
1)
A stable composition of the PCB matrix should be established.
-
2)
A possible time dependent change in composition of the matrix should first be excluded when used over different time periods.
Similar content being viewed by others
References
DeVoogt P.;Brinkman UATh (1989) Production, properties and usage of poly chlorinated biphenyls in Halogenated Biphenyls, Terphenyls, Naphtalenes, Dibenzodioxins and Related Products. 2nd ed.,Kimbrough R. D. andJensen A. A., Eds., Elsevier/ North-Holland, Amsterdam: 3–46
Ballschmitter K, Rappe C, Buser HR (1989) Chemical properties, analytical methods and environmental levels of PCBs, PCTs, PCNs and PBBs in Halogenated Biphenyls, Terphenyls, Naphtalenes, Dibenzodioxins and Related Products. 2nd ed.,Kim-Brough R. D. andJensen A. A., Eds., Elsevier/North-Holland, Amsterdam: 47–69
Hutzinger O, Blumich MJ;VandenBerg M., Olie K. (1985) Sources and fate of PCDDs and PCDFs: An overview. Chemosphere 14: 581–600
Rappe C, Buser HR (1989) Chemical and physical properties, analytical methods, sources and environmental levels of halogenated dibenzodioxins and dibenzofurans, in Halogenated Biphenyls, Terphenyls, Naphtalenes, Dibenzodioxins and Related Products. 2nd ed.,Kimbrough R. D. andJensen A. A., Eds., Elsevier/North-Holland, Amsterdam: 71–102
Norstrom RJ, Simon M, Muir DCG, Schweinberg RE (1988) Organochlorine contaminants in arctic food chains: Identification, geographical distribution, and temporal trends in polar bears. Env Sci Technol 22: 1063–1071
Braune BM, Norstrom RJ (1989) Dynamics of organochlorine compounds in Herring Gulls:III. Tissue distribution and bioaccumulation in Lake Ontario gulls. Env Toxicol Chem 8: 957 -968
VandenBerg M, Blank F, Heeremans C, Wagenaar H, Olie K (1987) Presence of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in fish-eating birds and fish from the Netherlands. Arch Environ Contam Toxicol 16: 149–158
Furst P, Meemken HA, Groebel W (1986) Determination of polychlorinated dibenzodioxins and dibenzofurans in human milk. Chemosphere 15: 1977–1980
VandenBerg M, VanderWielen FWM, Olie K, Boxtel CJ (1986) The presence of PCDDs and PCDFs in human breast milk from the Netherlands. Chemosphere 15: 693–706
Beck H, Echart K, Kellert M, Mathar W, Ruehl ChS, Wittkowski R (1987) Levels of PCDFs and PCDDs in samples of human origin and food in the Federal Republic of Germany. Chemosphere 16: 1977–1982
Thoma H, Mucke W, Kretschmer E (1989) Concentrations of PCDD and PCDF in human fat and liver samples. Chemosphere 18: 491–493
Safe S (1989): Polychlorinated aromatics: uptake, disposition and metabolism in Halogenated Biphenyls, Terphenyls, Naphtalenes, Dibenzodioxins and Related Products. 2nd ed.,Kimbrough R. D. andJensen A. A., Eds., Elsevier/North-Holland, Amsterdam: 131–159
VandenBerg M, DeJongh J, Poiger H, Olson, JR (1994) The toxicokinetics and metabolism of polychlorinated dibenzo-pdioxins (PCDDs) and dibenzofurans (PCDFs), and their relevance for toxicity. CRC Crit Rev Toxicol: 1–74
Safe S (1986) Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Ann Rev Pharmacol Toxicol 26: 371–399
Safe S (1990) Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit Rev Toxicol 21: 51–88
Birnbaum LS, Harris MW, Barnhart ER, Morrissey RE (1987) Teratogenicity of three polychlorinated dibenzofurans in C57BL/6N mice. Toxicol Appl Pharmacol, 90: 206–216
Poiger H, Pluess N, Schlatter C (1989) Subchronic toxicity of some chlorinated dibenzofurans in rats. Chemosphere 18: 265–275
Bol J, VandenBerg M, Seinen W (1989) Interactive effects of PCDDs, PCDFs and PCBs as assessed by the E.L.S. -Bioassay. Chemosphere 19: 899–906
Norén K, Lunden A, Sjövall J, Bergmann A (1990) Coplanar polychlorinated biphenyls in Swedish human milk. Chemosphere 20: 935–941
Dewailly E, Weber J-P, Gingras S, Laliberté C (1991) Coplanar PCBs in human milk in the province of Québec, Canada: are they more toxic than dioxin for breast fed infants? Bull Environ Contam Toxicol 47: 491–498
Norén K, Lundén A (1991) Trend studies of polychlorinated biphenyls, dibenzo-p-dioxins and dibenzofurans in human milk. Chemosphere 23: 1895–1901
Duarte-Davidson R, Harrad SJ, Allen SC, Jones KC (1992) The relative contribution of individual PCBs, PCDDs and PCDFs to toxic equivalent values derived for bulked human breast milk samples from the UK. Chemosphere 25: 1653–1663
Beck H, Dross A, Mathar W (1989) 3,3′,4,4′-tetrachlorobiphenyl in human fat and milk samples. Chemosphere 19: 1805–1810
Liem AKD, DeJong APJM, Marsman JA, DenBoer AC, Groenemeijer GS, DenHartog RS, DeKorte GAL, Hoogerbrugge R, Kootstra PR, Van ’t Klooster HA (1990) A rapid clean-up procedure for the analysis of polychlorinated dibenzo-p-dioxins and dibenzofurans in milk samples. Chemosphere 20: 843–850
Duarte-Davidson R, Burnett V, Waterhouse KS, Jones KC (1991) A congener specific method for the analysis of polychlorinated biphenyls (PCBs) in human milk. Chemosphere 23: 119–131
Matsueda T, Iida T, Hirakawa H, Fukamachi K, Tokiwa H, Nagayama J (1992) Comparison of concentrations of PCDDs, PCDFs and coplanar PCBs in breast milk of Yusho patients and normal controls. Organohalogen compounds 9. Finnish Institute of Occupational Health, Helsinki: 143–146
Hansson M, Holma S, Rappe C (1993) Isomer specific analysis of mono-ortho and non-ortho PCBs, PCDDs and PCDFs in human blood plasma. Organohalogen compounds 11. Eds.Fiedler H, Frank H, Hutzinger O, Perzefall W, Riss A, Safe S. Federal Environmental Agency, Austria: 177–180
Tuinstra LGMTh, Koopman-Esseboom C, Sauer PJJ, Huisman M (1993) Contents of dioxins, planar and other PCBs in human milk from the Rotterdam and Groningen area. Organohalogen compounds 11. Eds.Fiedler H, Frank H, Hutzinger O, Perzefall W, Riss A, Safe S. Federal Environmental Agency, Austria: 59–62
Johansen HR, Becher G, Polder A, Skare JU (1993) Congener specific determination of polychlorinated biphenyls in Norwegian human milk. Organohalogen compounds 11. Eds.Fiedler H, Frank H, Hutzinger O, Perzefall W, Riss A, Safe S. Federal Environmental Agency, Austria: 185–188
Tuinstra LGMTh, van Rhijn JA,Traag WA, v.d.Spreng P, Zuidema T, Horstmann HJ (1993) Method for the determination of dioxins, planar and other PCBs in human milk. Organohalogen compounds 11. Eds.Fiedler H, Frank H, Hutzinger O, Perzefall W, Riss A, Safe S. Federal Environmental Agency, Austria: 181–184
Bosveld ATC, VandenBerg M (1994) Biomarkers and bioassays as alternative screening methods for the presence and effects of PCDDs, PCDFs and PCBs. Fresenius’ J Anal Chem 348: 106–110.
VandenBerg M, Craane LHJ, Sinnige Th, VanMourik S, Dirksen S, Boudewijn Th, VanderGaag M, Lutke-Schipholt IJ, Spenkelink B, Brouwer A (1994) Biochemical and toxic effects of polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) in the Cormorant (Phalacrocorax carbo)alter in ovo exposure. Environ. Toxicol. Chem. 13: 803–816
Ahlborg UG, Becking GC, Birnbaum LS, Brouwer A, Derks HJGM, Feeley M, Golor G, Hanberg A, Larsen JC, Liem AKD, Safe SH, Schlatter C, Waern F, Younes M, Yrjänheikke E (1994) Toxic equivalency factors for dioxin-like PCBs. Chemosphere 28: 1049–1067
Safe SH (1994) Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit Rev Toxicol 24: 87–149
Wold S, Albano C, Dunn IIIWJ, Edlund U, Esbensen K, Geladi P, Hellberg S, Johannsson E, Lindgren W, Sjöström M (1984) Multivariate Analysis in Chemistry, NATO ASI Series C138. Riedel, Dordrecht, Holland, 4–96
World Health Organization — Regional Office for Europe 1989, Levels of PCBs, PCDDs, and PCDFs in Breast Milk, Environmental Health Series no. 34. Ed. E.J. Yrjänheikki
Dewailly E, Tremblay-Rousseau H, Carrier G, Groulx S, Gingras S, Bogess K, Stanley J, Weber JP (1990) PCDDs, PCDFs and PCBs in human milk of women exposed to a PCB fire and of women from the general population of the province of Quebec — Canada in Organohalogen Compounds, edsO. Hutzinger andH. Fiedler. Ecoinforma Press: Bayreuth 227–230
Author information
Authors and Affiliations
Additional information
This research project was supported by The Dutch Ministry of Housing, Physical Planning and the Environment. Grant no. 361359.
Rights and permissions
About this article
Cite this article
van den Berg, M., Sinnige, T.L., Tysklind, M. et al. Individual PCBs as predictors for concentrations of non and mono-ortho PCBs in human milk. Environ. Sci. & Pollut. Res. 2, 73–82 (1995). https://doi.org/10.1007/BF02986720
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02986720