Abstract
TheSchizonepeta tenuifolia spikes (STS) have been used as a traditional folk medicine for anti-inflammatory, analgesic, anti-pyretic and anti-spasmodic purpose in Korea. Phytosterols (mixture of campesterol 3.68%, stigmasterol 2.30% and β-sitosterol 94.02%) and hesperidin were isolated by chromatography from ether and n-BuOH fractions of STS respectively. These compounds significantly reduced the blood glucose level and lessened the loss of body weight and water consumption dose-dependently when administered at a i.p. doses of 10 and 20 mg/kg for 4 days after the i.v. injection of streptozotocin (180 mg/kg). In the morphologic study, these compounds showed protective activity on the pancreatic islets, especially β-cells, from the degenerative changes by streptozotocin.
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Kim, CJ., Lim, JS. & Cho, SK. Anti-diabetic agents from medicinal plants inhibitory activity ofSchizonepeta tenuifolia spikes on the diabetogenesis by streptozotocin in mice. Arch. Pharm. Res. 19, 441–446 (1996). https://doi.org/10.1007/BF02986008
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DOI: https://doi.org/10.1007/BF02986008