Skip to main content
Log in

Usefulness of201Tl and99mTc MIBI scintigraphy in a case of oncogenic osteomalacia

  • Case Report
  • Published:
Annals of Nuclear Medicine Aims and scope Submit manuscript

Abstract

A 45-year-old male was admitted with difficulty in walking due to leg pain. At the time of the first visit, a reduced serum phosphorus concentration and an increased serum alkaline phosphatase concentration of unknown etiology were observed. Either a whole body bone scintigraphy or CT of the neck, chest and abdominal region did not reveal any underlying disease. However both the whole body201T1 scintigraphy and99mTc MIBI SPECT showed accumulation in the right knee region, and a small tumor was detected by MRI examination. After a diagnosis of oncogenic osteomalacia due to this tumor was determined the tumor was surgically removed, and turned out to be a hemangiopericytoma. By removal of the tumor, either the symptoms or the laboratory data were improved significantly. In this case, both201T1 scintigraphy and99mTc scintigraphy MIBI were useful in identifying the location of the tumor which caused oncogenic osteomalacia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Prader VA, Illing R, Uehlinger E, Stalder G. Rachitis infolge Knochentumors.Helv Paediatr Acta 1959; 14: 554–565.

    PubMed  CAS  Google Scholar 

  2. Drezner MK. Tumor-induced rickets and osteomalacia. In:Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Fravus MJ (ed), 3rd ed. Philadelphia; Lippincott-Raven, 1996: 319–325.

    Google Scholar 

  3. Dorfman HD, Czerniak B.Bone tumors. St. Louis; Mosby, 1998; 1111–1119.

    Google Scholar 

  4. Sundarman M, McCarthy EF. Oncogenic osteomalacia.Skeletal Radiol 2000; 29: 117–124.

    Article  Google Scholar 

  5. Econs MJ, Drezner MK. Tumor-induced osteomalacia-unveiling a new hormone.N Engl J Med 1994; 330: 1679–1681.

    Article  PubMed  CAS  Google Scholar 

  6. Nuovo MA, Dorfman HD, Sun CJ, Chalew SA. Tumor-induced osteomalacia and rickets.Am J Surg Pathol 1989; 13:588–599.

    Article  PubMed  CAS  Google Scholar 

  7. Nakahama H, Nakanishi T, Uno H, Takaoka T, Taji N, Uyama O, et al. Prostate cancer-induced oncogenic hypo-phosphatemic osteomalacia.Urol Int 1995; 55: 38–40.

    Article  PubMed  CAS  Google Scholar 

  8. Weinder N, Bar RS, Weiss D, Strottmann MP. Neoplastic pathology of oncogenic osteomalacia/rickets.Cancer 1985; 55: 1691–1705.

    Article  Google Scholar 

  9. Weinder N, Cruz DS. Phosphaturic mesenchymal tumors; A polymorphous group causing osteomalacia or rickets.Cancer 1987; 59: 1442–1454.

    Article  Google Scholar 

  10. Avila NA, Skarulis M, Rubino DM, Doppman JL. Oncogenic osteomalacia: Lesion detection by MR skeletal surveyAJR 1996: 167:343–345.

    PubMed  CAS  Google Scholar 

  11. Ohta H. Nakanishi S, Oki S, Simizu M, Watanabe H, Fujikawa S, et al. Bone scintigraphy in a case of oncogenous osteomalacia.Clin Nucl Med 1998; 23: 467–469.

    Article  PubMed  CAS  Google Scholar 

  12. Sandhu FA, Martuza RM. Craniofocal hemangiopericytoma associated with oncogenic osteomalacia: case report.J Neur-Oncol 2000; 46: 241–247.

    Article  CAS  Google Scholar 

  13. Nguyen BD, Wang EA. Indium-111 pentetreotide scintigraphy of mesenchymal tumor with oncogenic osteomalacia.Clin Nucl Med 1999; 24: 130–131.

    Article  PubMed  CAS  Google Scholar 

  14. Yaghmai I. Angiographic manifestation of soft-tissue and osseous hemangiopericytomas.Radiology 1978; 126: 653–659.

    PubMed  CAS  Google Scholar 

  15. Levin DC, Gordon DH, McSweeney J. Arteriography of peripheral hemangiomas.Radiology 1976; 121: 625–630.

    PubMed  CAS  Google Scholar 

  16. Prando A, deSantos LA, Wallace S, Murray JA. Angiography in giant-cell bone tumors.Radiology 1979; 130: 323–331.

    PubMed  CAS  Google Scholar 

  17. Ozcan Z, Burak Z, Erinc R, Dirlik A, Basdemir G, Sabah D, et al. Correlation of99mTc-sestamibi uptake with blood-pool and osseous phase99mTc-MDP uptake in malignant bone and soft-tissue tumors.Nucl Med Commun 2001; 22: 679–683.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kimizuka, T., Ozaki, Y. & Sumi, Y. Usefulness of201Tl and99mTc MIBI scintigraphy in a case of oncogenic osteomalacia. Ann Nucl Med 18, 63–67 (2004). https://doi.org/10.1007/BF02985616

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02985616

Key words

Navigation