Thymulin (formerly called FTS) is a well defined nonapeptide hormone produced by thymic epithelial cells. Us biological activity and antigenicity depend upon the presence of the metal zinc in the molecule. This pharmacologically active metallopeptide induces the differentiation of T-cells and enhances several functions of the various T-cell subsets in normal or partially thymus-deficient recipients. Its effect on suppressor T-cells is, so far, the most remarkable and should be the first to find useful clinical applications. The peptide is a natural hormone, available in synthetic form. It is not toxic and one may foresee its clinical use as one of the major immunoregulatory agents in the near future.
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Bach J F: Thymulin (FTS-Zn).Clin Immun Allergy 3, 1 (1983).
Bach J F, Dardenne M, Pléau J M, Pléau Rosa: Biochemical characterization of a serum thymic hormone.Nature 266, 55 (1977).
Pléau J M, Dardenne M, Blouquit Y, Bach J F: Structural study of circulating thymic factor: a peptide isolated from pig serum. II. Aminoacid sequence.J biol Chem 252, 8045 (1977).
Dardenne M, Pléau J M, Nabarra B, Lefrancier P, Derien M, Choay J, Bach J F: Contribution of zinc and other metals to the biological activity of the serum thymic factor.Proc natn Acad Sci USA 79, 5370 (1982).
Cung M T, Marraud M, Lefrancier P, Dardenne M, Bach J F, Laussac J P: NMR study of a lymphocyte differentiating thymic factor. An investigation of the Zn (II)-nonapeptide complexes (thymulin).J biol Chem 263, 5574 (1988).
Savino W, Dardenne M, Pepiernik M, Bach J F: Thymic hormone-containing cells. Characterization and localization of serum thymic factor in young mouse thymus studied by monoclonal antibodies.J exp Med 156, 628 (1982).
Bordigoni P, Faure G, Bene M C, Dardenne M, Bach J F, Duheille J F, Olive D: Improvement of cellular immunity and IgA production in immunodeficient children after treatment with synthetic serum thymic factor (FTS).Lancet ii, 293 (1982).
Amor B, Dougados M, Mery C, De Gery A, Choay J, Dardenne M, Bach J F: Thymulin (FTS) in rheumatoid arthritis.Arthritis Rheum 27, 117 (1984).
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Bach, JF., Dardenne, M. Thymulin, a zinc-dependent hormone. Med. Oncol. & Tumor Pharmacother. 6, 25–29 (1989). https://doi.org/10.1007/BF02985220
- Thymic hormone