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Distinct different intra-tumor distribution of FDG between early phase and late phase in mouse fibrosarcoma

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Abstract

An early image of intra-tumor distribution of14C-labeled fluorodeoxy glucose (14C-FDG) was compared with a late image of18F-labeled FDG (18F-FDG) using mouse fibrosarcoma. Heterogeneous intra-tumor distribution of14C-FDG was observed 1 minute post injection of the tracer, whereas relatively homogeneous distribution of18F-FDG was seen 30 minutes later.14C-FDG was particularly taken up in the peripheral part of the tumor immediately after the tracer injection. A gradual and significant increase in18F-FDG accumulation with time was seen in the central part of tumor, which indicated an enhancement of anaerobic glycolysis. An initial uptake of18F-FDG was also compared with distribution of14C-iodoantipyrine and14C-thymidine uptake. Intratumoral distribution of initial uptake of18F-FDG showed almost the same regional distribution of14C-iodoantipyrine. A similar distribution of14C-thymidine as the initial uptake of18F-FDG was also observed. These results indicated that a high initial FDG uptake area seemed to be highly proliferative. A significant difference in the intratumoral distribution of FDG between early phase and late phase seemed to be related to heterogeneous biological characteristics of tumor cells.

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Authors and Affiliations

  1. Course of Allied Health Sciences, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, 565-0871, Suita, Osaka, JAPAN

    Osamu Inoue, Miho Shukuri, Rie Hosoi & Misato Amitani

  2. Department of Molecular Pathology, Course of Allied Health Sciences, Graduate School of Medicine, Osaka University, JAPAN

    Nariaki Matsuura

  3. Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Osaka University, JAPAN

    Jun Hatazawa

  4. Heavy-Ion Radiobiology Research Group, National Institute of Radiological Sciences, JAPAN

    Nobuhiko Takai

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  1. Osamu Inoue
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  2. Miho Shukuri
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  3. Rie Hosoi
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  4. Misato Amitani
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  5. Nariaki Matsuura
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  6. Jun Hatazawa
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  7. Nobuhiko Takai
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Correspondence to Osamu Inoue.

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Inoue, O., Shukuri, M., Hosoi, R. et al. Distinct different intra-tumor distribution of FDG between early phase and late phase in mouse fibrosarcoma. Ann Nucl Med 19, 655–659 (2005). https://doi.org/10.1007/BF02985113

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  • DOI: https://doi.org/10.1007/BF02985113

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