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A case of malignant pheochromocytoma with early intense uptake and immediate rapid washout of99mTc-tetrofosmin characterizing the overexpression of anti-apoptotic Bcl-2

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Abstract

Defective apoptotic program due to the overexpression of the anti-apoptotic Bcl-2 protein of the outer mitochondrial membrane may be a cause of the poor response of malignant pheochromocytoma to131I-MIBG therapy. We report a case of malignant pheochromocytoma which showed early intense uptake and immediate rapid washout of99mTc-tetrofosmin characterizing the overexpression of anti-apoptotic Bcl-2 and which was refractory to131I-MIBG therapy.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari-ku, 537-8511, Osaka, Japan

    Shigetoshi Wakasugi, Kazuki Fukuchi, Atushi Noguchi, Masanori Takeshita & Terumi Hashizume

  2. Department of Urology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan

    Toshiaki Kinouchi

  3. Department of Pathology, Minoh Municipal Hospital, Japan

    Haruo Taniguchi

  4. Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Japan

    Kunihiko Yokoyama

Authors
  1. Shigetoshi Wakasugi
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  2. Toshiaki Kinouchi
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  3. Haruo Taniguchi
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  4. Kunihiko Yokoyama
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  5. Kazuki Fukuchi
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  6. Atushi Noguchi
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  7. Masanori Takeshita
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  8. Terumi Hashizume
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Correspondence to Shigetoshi Wakasugi.

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Wakasugi, S., Kinouchi, T., Taniguchi, H. et al. A case of malignant pheochromocytoma with early intense uptake and immediate rapid washout of99mTc-tetrofosmin characterizing the overexpression of anti-apoptotic Bcl-2. Ann Nucl Med 20, 325–328 (2006). https://doi.org/10.1007/BF02984651

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  • DOI: https://doi.org/10.1007/BF02984651

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