Abstract
Positron emission tomography (PET) using18F-fluorodeoxyglucose (FDG) is useful in cancer diagnosis owing to its sensitivity to the differences in glucose metabolic rate between benign and malignant diseases, especially in the lung. One pitfall in PET imaging of lung disease, however, is the overlap in metabolic rate of inflammatory and neoplastic entities. Paragonimiasis is a food-borne parasitic disease that causes the pulmonary and pleural inflammation. We present two cases of pulmonary paragonimiasis that showed high uptake suggestive of tumor on FDG-PET CT images, both confirmed on histopathology by visualization ofParagonimus westermani eggs in the involved tissues.
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Could MK, Maclean CC, Kuschner WG, Rydzak CE, Owens DK. Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions.JAMA 2001; 285: 914–924.
Kelly RK, Tran T, Holmstrom A, Murar J, Segurola RJ Jr. Accuracy and cost-effectiveness of [18F]-2-fluoro-deoxy-D-glucose positron emission tomography scan in potentially resectable non-small cell lung cancer.Chest 2004; 125: 1413–1423.
Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Uno K. Evaluation of F-18 fluorodeoxyglucose (FDG) PET scanning for pulmonary nodules less than 3 cm in diameter, with special reference to the CT images.Lung Cancer 2004; 45: 19–27.
Imdahl A, Jenkner S, Brink I, Nitzsche E, Stoelben E, Moser E, et al. Validation of FDG positron emission tomography for differentiation of unknown pulmonary lesions.Eur J Cardiothorac Surg 2001; 20: 324–329.
Goo JM, Im JG, Do KH, Yeo JS, Seo JB, Kim HY, et al. Pulmonary tuberculoma evaluated by means of FDG PET: findings in 10 cases.Radiology 2000; 216: 117–121.
Croft DR, Trapp J, Kernstine K, Kirchner P, Mullan B, Galvin J, et al. FDG-PET imaging and the diagnosis of non-small cell lung cancer in a region of high histoplasmosis prevalence.Lung Cancer 2002; 36: 297–301.
Watanabe S, Nakamura Y, Kariatsumari K, Nagata T, Sakata R, Zinnouchi S, et al. Pulmonary paragonimiasis mimicking lung cancer on FDG-PET imaging.Anticancer Res 2003; 23: 3437–3440.
Zhuang H, Duarte PS, Rebenstock A, Feng Q, Alavi A. Pulmonary clostridium perfringens infection detected by FDG positron emission tomography.Clin Nucl Med 2003; 28: 517–518.
Hsu CH, Lee CM, Wang FC, Lin YH. F-18 fluorode-oxyglucose positron emission tomography in pulmonary cryptococcoma.Clin Nucl Med 2003; 28: 791–793.
Wilkinson MD, Fulham MJ, McCaughan BC, Constable CJ. Invasive aspergillosis mimicking stage IIIA non-small-cell lung cancer on FDG positron emission tomography.Clin Nucl Med 2003; 28: 234–235.
Beggs AD, Hain SF. F-18 FDG-positron emission tomo-graphic scanning and Wegener’s granulomatosis.Clin Nucl Med 2002; 27: 705–706.
Talwar A, Mayerhoff R, London D, Shah R, Stanek A, Epstein M. False-positive PET scan in a patient with lipoid pneumonia simulating lung cancer.Clin Nucl Med 2004; 29: 426–428.
Kao CH, Tsai SC, Hung GU. Two incorrect FDG positron emission tomography interpretations of a pulmonary mass and mediastinal lymphadenopathy.Clin Nucl Med 2001; 26: 1049–1050.
Patz EF Jr, Lowe VJ, Hoffman JM, Paine SS, Burrowes P, Coleman RE, et al. Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning.Radiology 1993; 188: 487–490.
Hubner KF, Buonocore E, Gould HR, Thie J, Smith GT, Stephens S, et al. Differentiating benign from malignant lung lesions using “quantitative” parameters of FDG PET images.Clin Nucl Med 1996; 21: 941–949.
Yang SN, Liang JA, Lin FJ, Kwan AS, Kao CH, Shen YY. Differentiating benign and malignant pulmonary lesions with FDG-PET.Anticancer Res 2001; 21: 4153–4157.
Schillaci O, Simonetti G. Fusion imaging in nuclear medicine-application of dual-modality systems in oncology.Cancer Biother Radiopharm 2004; 19: 1–10.
Zhuang H, Pourdehnad M, Lambright ES, Yamamoto AJ, Lanuti M, Li P, et al. Dual time point18F-FDG PET imaging for differentiating malignant from inflammatory processes.J Nucl Med 2001; 42: 1412–1417.
Kubota K, Itoh M, Ozaki K, Ono S, Tashiro M, Yamaguchi K, et al. Advantage of delayed whole-body FDG-PET imaging for tumour detection.Eur J Nucl Med 2001; 28: 696–703.
Matthies A, Hickeson M, Cuchiara A, Alavi A. Dual time point18F-FDG PET for the evaluation of pulmonary nodules.J Nucl Med 2002; 43: 871–875.
Mukae H, Taniguchi H, Matsumoto N, Iiboshi H, Ashitani J, Matsukura S, et al. Clinicoradiologic features of pleuro-pulmonaryParagonimus westermani on Kyusyu Island, Japan.Chest 2001; 120: 514–520.
DeFrain M, Hooker R. North American paragonimiasis, case report of a severe clinical infection.Chest 2002; 121: 1368–1372.
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Yoo, I.R., Park, H.J., O, J.H. et al. Two cases of pulmonary paragonimiasis on FDG-PET CT imaging. Ann Nucl Med 20, 311–315 (2006). https://doi.org/10.1007/BF02984648
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DOI: https://doi.org/10.1007/BF02984648