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Heredity of cancer susceptibility in mice

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VII. Conclusions

1. In confirmation of previous investigations, the breeding experiments of the present author have shown that cancer susceptibility in mice is hereditary.

2. No reason was found in favour of the idea of cancer being dominant, if it is a simple mendelian character.

3. Evidence is presented in favour of the hypothesis of multiplicity of controlling hereditary factors. This makes the problem of dominance extremely complex, but less urgent from the practical point of view.

4. Various histological types of tumours present considerable differences in their hereditary behaviour.

5. Since the males can be potentially cancerous but behaving as cancer-free, they must not be computed together with the females when mammary gland adenocarcinoma is concerned.

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Authors and Affiliations

  1. Institute of Radium, University of Paris, Rosenthal Laboratory, France

    N. Dobrovolskaïa-Zavadskaïa M.D.

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  1. N. Dobrovolskaïa-Zavadskaïa M.D.
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Read before the Sixth International Congress of Genetics at Ithaca, N.Y., August 24–31, 1932.

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Dobrovolskaïa-Zavadskaïa, N. Heredity of cancer susceptibility in mice. Journ. of Genetics 27, 181–198 (1933). https://doi.org/10.1007/BF02984411

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