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The prognosis significance of cathepsin-d expression in the different locations in axillary nodes negative carcinoma

  • Clinical Observation
  • Published:
Chinese Journal of Cancer Research

Abstract

Objective: The aim of this study was to investigate Cathepsin-D (Cath-D) expression in different location and its relationship with prognosis in the axillary lymph nodes negative (ANN) breast cancer patients. Methods: Cath-D expression in 192 cases of breast carcinoma were examined by immunohistochemistry. Depending on different parts of expression, three evaluating methods were used, compared and analysed. Results: The positive rate of Cath-D expression in ANN breast cancer with poor prognosis group and axillary nodes positive (ANP) group were significantly higher than that in ANN breast cancer with good prognosis group (x 2=23.20,P<0.01), while there was no significant difference between ANP group and ANN with poor prognosis group (x 2=0.19,P>0.05). Cath-D expression in stromal cells had no statistical difference among the three groups (x}2=1.56,P>0.05). When the Cath-D expression in cancer and stromal cells were counted into the positive rate, it was near the same (u 1=0.47,u 2=1.41,P>0.05). Conclusion: These results suggest that Cath-D expression is one of the powerful prognostic markers in ANN breast cancer. It’s a reliable, practical, and convenient method to observe and evaluate Cath-D expression in cancer cells.

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Authors and Affiliations

  1. Department of Breast Cancer Pathology, Tianjin Tumor Hospital, Tianjin Medical University, 300060, Tianjin

    Niu Yun, Fu Xi-lin & LÜ A-juan

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  1. Niu Yun
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  2. Fu Xi-lin
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  3. LÜ A-juan
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Correspondence to Niu Yun.

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Biography: NIU Yun (1958-), associate professor, Tianjin Tumor Hospital, majors in breast cancer.

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Niu, Y., Fu, Xl. & LÜ, Aj. The prognosis significance of cathepsin-d expression in the different locations in axillary nodes negative carcinoma. Chin J Cancer Res 13, 212–216 (2001). https://doi.org/10.1007/BF02983888

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  • DOI: https://doi.org/10.1007/BF02983888

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