International Journal of Hematology

, Volume 78, Issue 3, pp 226–232 | Cite as

Radiation Protective Effect of an Extract fromChelidonium majus

  • Jie-Young Song
  • Hyun-Ok Yang
  • Ji-Young Shim
  • Ji-Yeon Ahn
  • Young-Soo Han
  • In-Sung Jung
  • Yeon-Sook Yun
Progress in Hematology


We earlier reported that CM-AIa isolated fromChelidonium majus had mitogenic activity, generated lymphokine-activated killer cells, and increased the number of granulocyte-macrophage colony-forming cells (GM-CFC). In an extended effort to search for other immunostimulatory effects, we evaluated the protective effects of in vivo injected CM-AIa against irradiation. CM-AIa was found to increase the number of bone marrow cells, spleen cells, GM-CFC, and platelets in irradiated mice. In addition, this agent induced endogenous production of cytokines such as interleukin 1 and tumor necrosis factor a, which are required for hematopoietic recovery. We also demonstrated that CM-AIa treatment 24 hours before irradiation protected mice with 80% survival at lethal dose 100/15. These findings indicate that CM-AIa may be a useful agent for reducing the time needed for reconstitution of hematopoietic cells after irradiation treatment.

Key words

Chelidonium majus Immunomodulator Hematopoietic Irradiation 


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Copyright information

© The Japanese Society of Hematology 2003

Authors and Affiliations

  • Jie-Young Song
    • 1
  • Hyun-Ok Yang
    • 2
  • Ji-Young Shim
    • 1
  • Ji-Yeon Ahn
    • 1
  • Young-Soo Han
    • 1
  • In-Sung Jung
    • 1
  • Yeon-Sook Yun
    • 1
  1. 1.Laboratory of ImmunologyKorea Institute of Radiological and Medical SciencesSeoulKorea
  2. 2.Department of Anesthesiology and Pain Medicine, onCollege of MedicineUniversity of UlsanSeoulKorea

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