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Systemic Vasculitis with Renal Involvement — A Review

Irish Journal of Medical Science volume 158, pages 300–303 (1989)Cite this article

Summary

Twenty five patients with renal vasculitis presenting over an eight year period were reviewed. Ten had microscopic polyarteritis, 6 classic polyarteritis, 5 overlap syndrome, 2 Churg-Strauss syndrome and 2 Wegener’s granulomatosis. Clinical features included hypertension, pulmonary involvement, neurological involvement and arthralgia. Serum creatinine was over 500 umol/1 in 13 patients, 10 of whom required dialysis. Visceral angiography was positive in 80% of those studied, Focal and segmental necrotising glomerulonephritis was the commonest renal lesion. Treatment consisted of corticosteroids and cytotoxic agents in most cases. Plasmapheresis was used for rapidly progressive renal failure, severe pulmonary haemorrhage or cerebral vasculitis. Improvement or stabilisation of renal function was seen in 68% of patients treated. There were 4 early deaths and one late death. The diagnosis, histology, treatment and outcome of renal vasculitis is discussed. The importance of early diagnosis and treatment is emphasised in this potentially reversible cause of acute renal failure.

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Affiliations

  1. Departments of Pathology and Nephrology, Beaumont Hospital, Dublin 9

    Y. O’Meara, A. Green, M. Carmody, G. Doyle & J. Donohoe

Authors
  1. Y. O’Meara
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  2. A. Green
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  3. M. Carmody
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  4. G. Doyle
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  5. J. Donohoe
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O’Meara, Y., Green, A., Carmody, M. et al. Systemic Vasculitis with Renal Involvement — A Review. I.J.M.S. 158, 300–303 (1989). https://doi.org/10.1007/BF02983692

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  • DOI: https://doi.org/10.1007/BF02983692

Keywords

  • Vasculitis
  • Systemic Vasculitis
  • Polyarteritis Nodosa
  • Henoch Schonlein Purpura
  • Fibrinoid Necrosis