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International Journal of Hematology

, Volume 78, Issue 4, pp 370–373 | Cite as

Chronic Graft-versus-Host Disease following Varicella-Zoster Virus Infection in Allogeneic Stem Cell Transplant Recipients

  • Noriaki Kawano
  • Hisashi Gondo
  • Tomohiko Kamimura
  • Kenichi Aoki
  • Tadafumi Iino
  • Fumihiko Ishikawa
  • Toshihiro Miyamoto
  • Koji Nagafuji
  • Kazuya Shimoda
  • Shin Hayashi
  • Teruhisa Otsuka
  • Yukumasa Kazuyama
  • Mine Harada
Case Report

Abstract

We describe 2 allogeneic stem cell transplantation patients who developed chronic graft-versus-host disease (GVHD) after dermatomal varicella-zoster virus (VZV) infection. Localized zoster did not respond to oral valaciclovir but did resolve with intravenous aciclovir. However, skin eruptions, eye/oral dryness, and liver dysfunction were observed at the healing stage of localized zoster, suggesting development of GVHD. Intensification of immunosuppressive therapy was required to control GVHD. Quantitative real-time PCR for VZV DNA was used to distinguish liver involvement by chronic GVHD from visceral dissemination of VZV in 1 patient. VZV infection may trigger chronic GVHD after allogeneic stem cell transplantation.

Key words

Varicella-zoster virus Herpes zoster Allogeneic stem cell transplantation Quantitative real-time PCR 

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Copyright information

© The Japanese Society of Hematology 2003

Authors and Affiliations

  • Noriaki Kawano
    • 1
  • Hisashi Gondo
    • 1
  • Tomohiko Kamimura
    • 2
  • Kenichi Aoki
    • 1
  • Tadafumi Iino
    • 1
  • Fumihiko Ishikawa
    • 1
  • Toshihiro Miyamoto
    • 1
  • Koji Nagafuji
    • 1
  • Kazuya Shimoda
    • 1
  • Shin Hayashi
    • 2
  • Teruhisa Otsuka
    • 1
  • Yukumasa Kazuyama
    • 3
  • Mine Harada
    • 1
  1. 1.Medicine and Biosystemic ScienceKyushu University Graduate School of Medical SciencesFukuokaJapan
  2. 2.Department of HematologyHarasanshin General HospitalFukuoka
  3. 3.Kitasato Otsuka Biomedical Assay LaboratoriesTokyoJapan

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