Rituximab Treatment for Relapsed Autoimmune Hemolytic Anemia in Evans Syndrome


A case is reported of idiopathic relapsed autoimmune hemolytic anemia successfully treated with rituximab.A 43-year-old white male patient with past medical history of Evans syndrome was found to have recurrent autoimmune hemolytic anemia. Previous treatments included steroids, splenectomy, intravenous immunoglobulin, plasmapheresis, staphylococcal Protein A immunoadsorption (Prosorba column), and chemotherapeutic agents (cytoxan and vincristine). Rituximab was given weekly at 375 mg/m2 for 4 doses.The drug was well tolerated and the patient remains in remission 9 months after completion of therapy.

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Correspondence to Anat Galor or Timothy O’Brien.

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Galor, A., O’Brien, T. Rituximab Treatment for Relapsed Autoimmune Hemolytic Anemia in Evans Syndrome. Int J Hematol 78, 335–336 (2003). https://doi.org/10.1007/BF02983558

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Key words

  • Rituximab
  • Immune hemolytic anemia