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International Journal of Hematology

, Volume 79, Issue 1, pp 52–54 | Cite as

Coexistent Rearrangements of c-MYC,BCL2, andBCL6 Genes in a Diffuse Large B-Cell Lymphoma

  • Chiyoko Ueda
  • Momoko Nishikori
  • Toshio Kitawaki
  • Takashi Uchiyama
  • Hitoshi Ohno
Case Report

Abstract

We present a patient with stage III de novo diffuse large B-cell lymphoma. The lymphoma cells showed mature B-cell immunophenotype but lacked surface immunoglobulin (Ig) expression. Long-distance and long-distance inverse polymerase chain reaction assays to detect the oncogene/Ig gene rearrangement revealed that the cells carried 3 independent fusion genes, namely, c-MYC/Ig heavy chain gene (IgH), BCL2/IgH, and Ig λ light chain gene/BCL6.Thus, the lymphoma cells concurrently carried t(8;14)(q24;q32), t(14;18)(q32;q21), and t(3;22)(q27;q11), which developed in association with class switching, V/D/J recombination, and somatic hypermutation, respectively. The lymphoma responded to chemoradiotherapy, and the patient has been well for 2 years, suggesting that multiple oncogene rearrangements may not necessarily be associated with poor clinical outcome.

Key words

Diffuse large B-cell lymphoma c-MYC BCL2 BCL6 Long-distance PCR 

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Copyright information

© The Japanese Society of Hematology 2004

Authors and Affiliations

  • Chiyoko Ueda
    • 1
  • Momoko Nishikori
    • 1
  • Toshio Kitawaki
    • 1
  • Takashi Uchiyama
    • 1
  • Hitoshi Ohno
    • 1
  1. 1.Department of Hematology and Oncology, Graduate School of MedicineKyoto UniversitySakyo-kuJapan

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